Sucralose (aka Splenda)

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24 Diseases Researched for Sucralose (aka Splenda)
6 Adverse Pharmacological Actions Researched for Sucralose (aka Splenda)
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View the Evidence:
35 Abstracts with Sucralose (aka Splenda) Research

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Pubmed Data : J Pediatr Gastroenterol Nutr. 2018 Mar ;66(3):466-470. PMID: 29077645
Study Type : Human Study
Additional Links
Additional Keywords : Breast Feeding, Microbiome, Risk Factors
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Pubmed Data : Nature. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25231862
Study Type : Animal Study, Human Study
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Pubmed Data : Am J Clin Nutr. 2017 Feb 22. Epub 2017 Feb 22. PMID: 28228424
Study Type : Human Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : J Toxicol Environ Health A. 2015 ;78(16):1029-32. Epub 2015 Aug 12. PMID: 26267522
Study Type : Human Study
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Pubmed Data : Diabetes Care. 2013 Apr 30. Epub 2013 Apr 30. PMID: 23633524
Study Type : Human Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Nov 24 ;14(23). Epub 2022 Nov 24. PMID: 36501030
Study Type : Human Study
Additional Links
Problem Substances : Aspartame, Sucralose (aka Splenda)
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Pubmed Data : Sci Total Environ. 2022 Jul 10 ;829:154689. Epub 2022 Mar 18. PMID: 35314215
Study Type : Animal Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Coll Physicians Surg Pak. 2019 Sep ;29(9):848-851. PMID: 31455480
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame, Sucralose (aka Splenda)
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Pubmed Data : Arch Oral Biol. 2013 Sep ;58(9):1116-22. Epub 2013 Apr 28. PMID: 23631998
Study Type : Animal Study
Additional Links
Diseases : Dental Caries
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Pubmed Data : Morphologie. 2018 Aug 2. Epub 2018 Aug 2. PMID: 30078469
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Hepatotoxic
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gut Microbes. 2023 ;15(1):2157698. PMID: 36524841
Study Type : Animal Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(7):e0199080. Epub 2018 Jul 5. PMID: 29975731
Study Type : Animal Study
Additional Links
Diseases : Dysbiosis
Additional Keywords : Microbiota
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Pubmed Data : Int J Occup Environ Health. 2016 Jan ;22(1):7-17. Epub 2016 Jan 29. PMID: 27078173
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Carcinogenic
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Pubmed Data : Food Chem Toxicol. 1990 Jun;28(6):449-55. PMID: 2210518
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Food Funct. 2021 Oct 4 ;12(19):9380-9390. Epub 2021 Oct 4. PMID: 34606537
Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Gastrotoxic
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Pubmed Data : Food Chem Toxicol. 2000;38 Suppl 2:S71-89. PMID: 10882819
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : PLoS One. 2014 ;9(4):e92771. Epub 2014 Apr 3. PMID: 24699280
Study Type : Insect Study
Additional Links
Additional Keywords : Lipid Peroxidation, Splenda, Sucralose
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Neurotoxic
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Nutr. 2016 Dec 31. Epub 2016 Dec 31. PMID: 28040879
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid, Neurotoxic
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Pubmed Data : Cell Metab. 2016 Jul 12 ;24(1):75-90. PMID: 27411010
Study Type : Animal Study
Additional Links
Diseases : Eating Disorders
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Food Chem Toxicol. 2000;38 Suppl 2:S53-69. PMID: 10882818
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Chemosphere. 2012 Jan ;86(1):50-5. Epub 2011 Sep 28. PMID: 21955350
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : J Toxicol Environ Health A. 2018 Aug 21:1-11. Epub 2018 Aug 21. PMID: 30130461
Study Type : Animal Study
Additional Links
Additional Keywords : Bioaccumulation
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : J Toxicol Environ Health A. 2008;71(21):1415-29. PMID: 18800291
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Brain Res. 2018 12 1 ;1700:181-189. Epub 2018 Sep 7. PMID: 30201258
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Neurotoxic
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Pubmed Data : Inflamm Bowel Dis. 2018 Mar 15. Epub 2018 Mar 15. PMID: 29554272
Study Type : Animal Study
Additional Links
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Pubmed Data : Proc Natl Acad Sci U S A. 2007 Sep 18 ;104(38):15075-80. Epub 2007 Aug 27. PMID: 17724332
Study Type : Animal Study
Additional Links
Additional Keywords : Cephalic Phase Effect
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Pubmed Data : Can J Gastroenterol. 2011 Sep ;25(9):511. PMID: 21912763
Study Type : Review
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Inflammatory
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Sep 25 ;23(10). Epub 2018 Sep 25. PMID: 30257473
Study Type : In Vitro Study
Additional Links
Additional Keywords : Microbiome
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Pubmed Data : World J Gastroenterol. 2012 Apr 21 ;18(15):1708-22. PMID: 22553395
Study Type : Review
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Inflammatory
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Pubmed Data : Chem Res Toxicol. 2019 Jun 17 ;32(6):1241-1249. Epub 2019 May 23. PMID: 31079450
Study Type : In Vitro Study
Additional Links
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Pubmed Data : Environ Sci Technol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21879743
Study Type : Review
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Environ Sci Technol. 2011 Jan 14. [Epub ahead of print]. PMID: 21235203
Study Type : In Vitro Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Headache. 2006 Sep;46(8):1303-4. PMID: 16942478
Study Type : Commentary
Additional Links
Problem Substances : Sucralose (aka Splenda)
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Pubmed Data : Physiol Behav. 2016 Apr 14. Epub 2016 Apr 14. PMID: 27090230
Study Type : Bacterial
Additional Links
Additional Keywords : Microbiota, Risk Factors
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Pubmed Data : Mutat Res. 2002 Aug 26;519(1-2):103-19. PMID: 12160896
Study Type : In Vitro Study

Sucralose (aka Splenda) Related Articles

Written by Sayer Ji, Founder
In the first study of its kind, Splenda (sucralose) has been found to have potential neurotoxic properties that could explain why it causes abnormal behavioral changes in aquatic animals
Written by Erin Chamerlik, MS
Is your yogurt damaging your health? Are these highly processed ingredients in your grocery store yogurt?
Avoid these sugar substitutes for breast cancer healing, prevention and a healthy, chemical-free lifestyle.
Written by Sayer Ji, Founder
Promoted for decades as a "safe" sugar alternative, presumably to prevent or reduce symptoms of diabetes, Splenda (sucralose) has been found to have diabetes-promoting effects in human subjects.
Written by GMI Reporter
FDA-approved artificial sweeteners and sport supplements have now been found to be toxic to digestive gut microbes, according to a new paper published in the journal Molecules
Written by Sayer Ji, Founder
A groundbreaking new study reveals that non-caloric artificial sweeteners (NAS) drive obesity- and diabetes-related changes in both mice and humans.
Food has lost its story. Stripped of context, meaning, and reduced to its molecular composition, ancient recipes for health and joy long to be recovered
Written by Sayer Ji, Founder
It is hard to imagine how anyone still consumes Splenda (sucralose), considering how damning the accumulating body of scientific evidence is showing that it is a SERIOUS threat to both human and environmental health. A new study adds GENOTOXICITY to the list of this chemical's many serious mechanisms of harm.
Written by Sayer Ji, Founder
A review on the synthetic sweetener sucralose (marketed as Splenda), published in the journal Toxicology and Environmental Health, overturns widely held misconceptions about the purported safety of this ubiquitous artificial sweetener.
Avoid these sugar substitutes for breast cancer healing, prevention and a healthy, chemical-free lifestyle.
Written by Sayer Ji, Founder
Is Splenda really a food, or a highly toxic chemical?
Written by Sayer Ji, Founder
Synthetic sweeteners have been linked to a wide range of health problems, with over 80 documented on the GreenMedInfo database, alone. The various mechanisms of their toxicity, however, have not yet been fully elucidated. A new study raises a disturbing possibility that these widely consumed chemicals are driving otherwise 'good bacteria' into developing potentially lethal antibiotic resistance through a gut-mediated process.
Written by Sayer Ji, Founder
A newly published study is destined to reignite the decades old controversy about aspartame's safety, or lack thereof. Aspartame converts to formaldehyde and formic acid, which are highly toxic to the body, but the nervous system in particular.
Written by Sayer Ji, Founder
So, you are looking to lose a few pounds, or keep them off. What better way to accomplish this feat than to eliminate both empty sugar calories and synthetic sweeteners, which studies show can generate excessive cravings for sweets and actually increase weight gain.
Written by Sayer Ji, Founder
A concerning new study finds that most of the breast milk samples tested contained artificial sweeteners. Why has this never been discovered until now and what are the implications to our most vulnerable populations?
Written by Sayer Ji, Founder
Sugar and artificial sweeteners are so accessible, affordable and socially sanctioned, that few consider their habitual consumption to be a problem on the scale of say, addiction to cocaine. But if recent research is correct, their addictive potential could be even worse.
Written by Sayer Ji, Founder
Sugar and artificial sweeteners are so accessible, affordable and socially sanctioned, that few consider their habitual consumption to be a problem on the scale of say, addiction to cocaine. But if recent research is correct, their addictive potential could be even worse.
Written by Tania Melkonian
While millions around the world consume foods and beverages sweetened with Splenda (sucralose) with abandon, an accumulating body of research indicates that this synthetic chemical is far from safe, may contribute to obesity and blood sugar disorders, and more recently has even been linked to leukemia in animal experiments.
Written by Sayer Ji, Founder
A concerning new study finds that most of the breast milk samples tested contained artificial sweeteners. Why has this never been discovered until now and what are the implications to our most vulnerable populations?
Written by Sayer Ji, Founder
A newly published study is destined to reignite the decades old controversy about aspartame's safety, or lack thereof. Aspartame converts to formaldehyde and formic acid, which are highly toxic to the body, but the nervous system in particular.
Written by Erin Chamerlik, MS
Is your yogurt damaging your health? Are these highly processed ingredients in your grocery store yogurt?
Written by Sayer Ji, Founder
So, you are looking to lose a few pounds, or keep them off. What better way to accomplish this feat than to eliminate both empty sugar calories and synthetic sweeteners, which studies show can generate excessive cravings for sweets and actually increase weight gain.
Written by Sayer Ji, Founder
Is Splenda really a food, or a highly toxic chemical?
Written by GMI Reporter
FDA-approved artificial sweeteners and sport supplements have now been found to be toxic to digestive gut microbes, according to a new paper published in the journal Molecules

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