Sulfonylureas

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12 Diseases Researched for Sulfonylureas

Name	AC	CK	Focus
Diabetes Mellitus: Type 2	9	160
Diabetes: Cardiovascular Illness	5	100
Coronary Artery Disease	3	80
Mortality: All-Cause	1	40
Weight Gain: Drug-Induced	1	40
Weight Problems: Drug-Induced	1	40
Cancers: All	1	30
Cardiac Mortality	2	20
Congestive Heart Failure	1	20
Hypoglycemia	1	20
Purpuric Dermatosis	1	3
Drug-Induced Toxicity	1	1

3 Adverse Pharmacological Actions Researched for Sulfonylureas

Name	AC	CK	Focus
Cardiotoxic	3	80
Hypoglycemic	1	20
Phototoxicity	1	1

Research Articles 13
Cumulative Knowledge Score 21
Overall Research Rating GOOD

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13 Abstracts with Sulfonylureas Research

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There is a trend toward an increased overall mortality risk with glyburide versus glimepiride and glipizide versus glimepiride (1.39 [0.99-1.96]) in those with documented coronary artery disease.Jun 01, 2010

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Pubmed Data : Diabetes Care. 2010 Jun;33(6):1224-9. Epub 2010 Mar 9. PMID: 20215447

Article Published Date : Jun 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Coronary Artery Disease, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2, Mortality: All-Cause

Problem Substances : Glipizide, Glyburide

Adverse Pharmacological Actions : Cardiotoxic

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Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of coronary artery disease in comparison to gliclazide or glimepiride.Dec 01, 2008

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Pubmed Data : Diabetes Res Clin Pract. 2008 Dec;82(3):391-5. Epub 2008 Oct 21. PMID: 18945509

Article Published Date : Dec 01, 2008

Study Type : Meta Analysis

Additional Links

Diseases : Coronary Artery Disease, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

Additional Keywords : Drug: Metformin

Problem Substances : Glibenclamide, Glipizide

Adverse Pharmacological Actions : Cardiotoxic

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Several drugs are associated with weight change of varying magnitudes. Jan 31, 2015

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Pubmed Data : J Clin Endocrinol Metab. 2015 Feb ;100(2):363-70. Epub 2015 Jan 15. PMID: 25590213

Article Published Date : Jan 31, 2015

Study Type : Meta Analysis, Review

Additional Links

Diseases : Weight Gain: Drug-Induced, Weight Problems: Drug-Induced

Additional Keywords : Risk Factors, Weight Loss

Problem Substances : Glipizide, Glyburide, Mirtazapine, Olanzapine, Pioglitazone (trade Name Actos), Quetiapine, Risperidone

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Sulfonylureas are associated with an increased risk of adverse cardiovascular events in type 2 diabetic patients.Jun 01, 2009

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Pubmed Data : Acta Diabetol. 2009 Jun;46(2):145-54. Epub 2009 Feb 5. PMID: 19194648

Article Published Date : Jun 01, 2009

Study Type : Meta Analysis

Additional Links

Diseases : Congestive Heart Failure, Coronary Artery Disease, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

Additional Keywords : Drug: Metformin

Problem Substances : Sulfonylureas

Adverse Pharmacological Actions : Cardiotoxic

[+]

A higher mortality was observed in patients treated with combinations of sulfonylureas and biguanides, even at low doses. Jan 01, 2004

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Pubmed Data : Diabetes Metab Res Rev. 2004 Jan-Feb;20(1):44-7. PMID: 14737744

Article Published Date : Jan 01, 2004

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2

Problem Substances : Biguanides, Sulfonylureas

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Anti-infectives may increase the risk of severe hypoglycemia in glipizide or glyburide users.Aug 01, 2010

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Pubmed Data : Clin Pharmacol Ther. 2010 Aug;88(2):214-22. Epub 2010 Jun 30. PMID: 20592722

Article Published Date : Aug 01, 2010

Study Type : Human Study

Additional Links

Diseases : Hypoglycemia

Additional Keywords : Drug-to-Drug Interactions

Problem Substances : Antibiotics, Cephalexin, Cipro, Clarithromycin, Co-trimoxazole, Fluconazole, Glipizide, Glyburide, Levofloxacin

Adverse Pharmacological Actions : Hypoglycemic

[+]

Glibenclamide in combination with metformin is associated with significantly higher mortality. Nov 01, 2006

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Pubmed Data : Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):477-82. PMID: 16634115

Article Published Date : Nov 01, 2006

Study Type : Human Study

Additional Links

Diseases : Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

Additional Keywords : Drug: Metformin

Problem Substances : Glibenclamide, Sulfonylureas

[+]

Metformin and sulfonylurea drugs are associated with adverse side effects such as lactic acidosis and hypoglycemia, including fatal incidences. Jan 01, 1985

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Pubmed Data : Horm Metab Res Suppl. 1985;15:105-11. PMID: 3935560

Article Published Date : Jan 01, 1985

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2

Additional Keywords : Drug: Metformin

Problem Substances : Metformin , Sulfonylureas

[+]

Patients with type 2 diabetes who use sulfonylureas or insulin have an increased risk for cancer-related mortality. Feb 01, 2006

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Pubmed Data : Diabetes Care. 2006 Feb;29(2):254-8. PMID: 16443869

Article Published Date : Feb 01, 2006

Study Type : Human Study

Additional Links

Diseases : Cancers: All, Diabetes Mellitus: Type 2

Additional Keywords : Drug: Metformin

Problem Substances : Glipizide, Glyburide, Insulin , Metformin , Sulfonylureas

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There is a higher cardiovascular mortality in Type II diabetic patients taking sulphonylurea and metformin in combination than in those taking only sulphonylurea.May 01, 2000

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Pubmed Data : Diabetologia. 2000 May;43(5):558-60. PMID: 10855529

Article Published Date : May 01, 2000

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality , Diabetes Mellitus: Type 2

Additional Keywords : Drug: Metformin

Problem Substances : Metformin , Sulfonylureas

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Type 2 diabetic patients with ischemic heart disease using metformin, alone or in combination with sulfonylureas, exhibited a significantly increased mortality.Jan 01, 1999

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Pubmed Data : Cardiology. 1999;91(3):195-202. PMID: 10516414

Article Published Date : Jan 01, 1999

Study Type : Human Study

Additional Links

Diseases : Cardiac Mortality , Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

Additional Keywords : Drug: Metformin

Problem Substances : Metformin , Sulfonylureas

[+]

A case of Glipizide-induced pigmented purpuric dermatosis has been reported.Nov 01, 1999

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Pubmed Data : J Am Acad Dermatol. 1999 Nov;41(5 Pt 2):827-9. PMID: 10534660

Article Published Date : Nov 01, 1999

Study Type : Human: Case Report

Additional Links

Diseases : Purpuric Dermatosis

Problem Substances : Glipizide

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Glipizide exhibits photoxicity in vitro.Jan 01, 2000

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Pubmed Data : In Vitr Mol Toxicol. 2000;13(1):17-24. PMID: 10900404

Article Published Date : Jan 01, 2000

Study Type : In Vitro Study

Additional Links

Diseases : Drug-Induced Toxicity

Problem Substances : Glipizide

Adverse Pharmacological Actions : Phototoxicity

Research Articles 13
Cumulative Knowledge Score 21
Overall Research Rating GOOD

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