Tamoxifen

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51 Diseases Researched for Tamoxifen
NameACCKFocus
Breast Cancer22142Locked
Endometrial Cancer17118Locked
Drug-Induced Toxicity 580Locked
Chemotherapy-Induced Toxicity: Tamoxifen1460Locked
Fatty Liver642Locked
Memory Disorders: Drug-Induced442Locked
Cognitive Decline/Dysfunction340Locked
Endometrial Neoplasms431Locked
Gastric Cancer322Locked
Amenorrhoea120Locked
Cataract120Locked
Memory Loss212Locked
Breast Cancer: Estrogen211Locked
Chemically-Induced Liver Damage211Locked
Chemotherapy-Induced Toxicity110Locked
Colorectal Cancer110Locked
Deep Vein Thrombosis110Locked
Leukemia: Acute myelogenous leukemia (AML) 110Locked
Nonalcoholic fatty liver disease (NAFLD)110Locked
Osteoporosis110Locked
Pulmonary Embolism110Locked
Sexual Dysfunction110Locked
DNA damage34Locked
Gastrointestinal Inflammation24Locked
Oxidative Stress24Locked
Liver Damage: Drug-Induced23Locked
Pancreatitis13Locked
Pneumonia: Drug-Induced13Locked
Pneumonia: Eosinophilic 13Locked
Triglycerides: Elevated13Locked
Abortion: Induced12Locked
Arsenic Poisoning12Locked
Bladder Cancer12Locked
Bone Diseases12Locked
Breast Cancer: Conventional Treatment12Locked
Cancers: Drug Resistant22Locked
Cervical Cancer12Locked
Infertility: Male12Locked
Learning disorders12Locked
Liver Cancer12Locked
Parkinson's Disease12Locked
Prenatal Chemical Exposures12Locked
Vaginal Cancer12Locked
Bisphenol Toxicity11Locked
Breast Cancer: Drug Resistant11Locked
Breast Cancer: Metastatic11Locked
Breast Cancer: Triple Negative 11Locked
Estrogen Deficiency11Locked
Estrogen Dominance11Locked
Tumors11Locked
Uterine Cancer 11Locked
13 Adverse Pharmacological Actions Researched for Tamoxifen
NameACCKFocus
Carcinogenic17111Locked
Neurotoxic340Locked
Hepatotoxic330Locked
Genotoxic516Locked
Mutagenic312Locked
Estrogen Agonist211Locked
Estrogenic211Locked
Carcinogen110Locked
Endocrine Disruptor12Locked
Oxidant12Locked
Proliferative11Locked
Tumorigenic11Locked
Uterotrophic11Locked
Related Topics

Tamoxifen is a Sub of the following Topic

View the Evidence:
68 Abstracts with Tamoxifen Research

[+]

Five or more years of tamoxifen use increases risk of cataracts in breast cancer patients.Mar 01, 2000

Pubmed Data : Breast Cancer Res Treat. 2000 Mar;60(2):167-72. PMID: 10845279
Article Published Date : Mar 01, 2000
Study Type : Meta Analysis
Additional Links
Diseases : Cataract, Drug-Induced Toxicity
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
[+]

Postoperative tamoxifen for ductal carcinoma in situ does not reduce overall mortality. Dec 31, 2011

Pubmed Data : Cochrane Database Syst Rev. 2012 ;10:CD007847. Epub 2012 Oct 17. PMID: 23076938
Article Published Date : Dec 31, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Breast Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
[+]

Tamoxifen interferes with cognitive function in breast cancer patients. Nov 01, 2000

Pubmed Data : Breast Cancer Res Treat. 2000 Nov;64(2):165-76. PMID: 11194452
Article Published Date : Nov 01, 2000
Study Type : Meta Analysis
Additional Links
Diseases : Cognitive Decline/Dysfunction, Drug-Induced Toxicity , Memory Disorders: Drug-Induced
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Neurotoxic
[+]

Tamoxifen use may cause endometrial cancer, as well as being associated with poorer prognosis. May 04, 1998

Pubmed Data : Int J Cancer. 1998 May 4;76(3):325-30. PMID: 9579567
Article Published Date : May 04, 1998
Study Type : Meta Analysis
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen was a risk factor for chemotherapy-induced amenorrhea.May 31, 2016

Pubmed Data : Acta Oncol. 2016 Jun ;55(6):664-70. Epub 2016 Apr 22. PMID: 27105082
Article Published Date : May 31, 2016
Study Type : Meta Analysis, Review
Additional Links
Diseases : Amenorrhoea, Chemotherapy-Induced Toxicity: Tamoxifen
Additional Keywords : Risk Factors
Problem Substances : Tamoxifen
[+]

Two year treatment with Tamoxifen and Arimidex result in a number of side effects which reduce quality of life. Dec 01, 2006

Pubmed Data : Breast Cancer Res Treat. 2006 Dec;100(3):273-84. Epub 2006 Jun 21. PMID: 16944295
Article Published Date : Dec 01, 2006
Study Type : Meta Analysis
Additional Links
Diseases : Drug-Induced Toxicity
Additional Keywords : Drug: Tamoxifen
Problem Substances : Arimidex, Tamoxifen
[+]

Adjuvant tamoxifen therapy for early stage breast cancer increases the risk of second primarly malignancies such as endometrial, colon and somatch cancer.May 03, 1995

Pubmed Data : J Natl Cancer Inst. 1995 May 3;87(9):645-51. PMID: 7752269
Article Published Date : May 03, 1995
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Colorectal Cancer, Endometrial Cancer, Gastric Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Correlation of the tamoxifen use with the increased risk of deep vein thrombosis and pulmonary embolism in elderly women with breast cancer.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2018 Dec ;97(51):e12842. PMID: 30572423
Article Published Date : Nov 30, 2018
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Deep Vein Thrombosis, Pulmonary Embolism
Additional Keywords : Increased Risk
Problem Substances : Tamoxifen
[+]

Memory deficits occur in breast cancer patients who receive either chemotherapy or tamoxifen.Sep 01, 2011

Pubmed Data : J Psychosoc Oncol. 2011 Sep-Oct;29(5):499-514. PMID: 21882931
Article Published Date : Sep 01, 2011
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity, Memory Disorders: Drug-Induced, Memory Loss
Anti Therapeutic Actions : Chemotherapy
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Neurotoxic
[+]

Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption.Feb 16, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cancer Res. 2015 Feb 17. Epub 2015 Feb 17. PMID: 25691730
Article Published Date : Feb 16, 2015
Study Type : Human Study
Additional Links
Substances : Caffeic Acid, Caffeine
Diseases : Breast Cancer, Breast Cancer: Estrogen
Pharmacological Actions : Anti-Tumor, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Estrogen Receptor Modulators, Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords : Dose Response, Risk Reduction
Problem Substances : Tamoxifen
[+]

Tamoxifen and Arimidex (anastrozole) can have detrimental effects on higher brain functions.Mar 24, 2010

Pubmed Data : J Clin Exp Neuropsychol. 2010 Mar 24:1-11. Epub 2010 Mar 24. PMID: 20336566
Article Published Date : Mar 24, 2010
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Cognitive Decline/Dysfunction
Problem Substances : Arimidex, Tamoxifen
[+]

Tamoxifen and raloxifene adversely affect cognitive function in older women.Mar 01, 2010

Pubmed Data : J Womens Health (Larchmt). 2010 Mar ;19(3):371-9. PMID: 20136553
Article Published Date : Mar 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cognitive Decline/Dysfunction
Anti Therapeutic Actions : Chemotherapy
Problem Substances : Raloxifene, Tamoxifen
[+]

Tamoxifen and toremifene treatment is significantly associated with reversible NAFLD in Asian women.Jul 31, 2016

Pubmed Data : Breast. 2016 Aug ;28:67-72. Epub 2016 May 27. PMID: 27240168
Article Published Date : Jul 31, 2016
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Tamoxifen, Fatty Liver, Nonalcoholic fatty liver disease (NAFLD)
Additional Keywords : Risk Factors
Problem Substances : Tamoxifen
[+]

Tamoxifen causes DNA adducs in the endometrium of women. Aug 01, 2000

Pubmed Data : Carcinogenesis. 2000 Aug;21(8):1461-7. PMID: 10910945
Article Published Date : Aug 01, 2000
Study Type : Human Study
Additional Links
Diseases : Endometrial Cancer, Endometrial Neoplasms
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic, Genotoxic, Mutagenic
[+]

Tamoxifen has been shown to cause endometrial cancer in humans.Mar 01, 2001

Pubmed Data : Eur J Obstet Gynecol Reprod Biol. 2001 Mar;95(1):105-10. PMID: 11267730
Article Published Date : Mar 01, 2001
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen increases the risk of endometrial hyperplasia and carcinoma in breast cancer patients.Jan 01, 2003

Pubmed Data : Vopr Onkol. 2003;49(2):198-204. PMID: 12785205
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen may induce fatty liver in patients with breast cancer.Jan 01, 2003

Pubmed Data : AJR Am J Roentgenol. 2003 Jan;180(1):129-34. PMID: 12490491
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Fatty Liver
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Hepatotoxic
[+]

Tamoxifen therapy has been associated with the development of acute myeloid leukemia during breast cancer treatment.Mar 01, 1997

Pubmed Data : Med Oncol. 1997 Mar;14(1):61-2. PMID: 9232614
Article Published Date : Mar 01, 1997
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Leukemia: Acute myelogenous leukemia (AML)
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen treatment for breast cancer in Japanese women results in an increased risk for endomentrial and stomach cancer.Dec 01, 2000

Pubmed Data : Ann Oncol. 2000 Dec;11(12):1537-43. PMID: 11205460
Article Published Date : Dec 01, 2000
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer, Gastric Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen treatment for breast cancer may result in fatty liver.Nov 01, 2000

Pubmed Data : Oncol Rep. 2000 Nov-Dec;7(6):1299-304. PMID: 11032933
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Fatty Liver
Additional Keywords : Drug: 5-flourouracil, Drug: Doxorubicin, Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Hepatotoxic
[+]

Tamoxifen treatment for breast cancer results in one-third of all patients developing endometrial polyps, hyperplasia, metaplasia, consistent with an estrogen-agonist effect.Aug 01, 2000

Pubmed Data : Gynecol Oncol. 2000 Aug;78(2):181-6. PMID: 10926800
Article Published Date : Aug 01, 2000
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer, Endometrial Neoplasms
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Estrogen Agonist, Estrogenic
[+]

Tamoxifen treatment in breast cancer may induce non-alcoholic fatty liver.May 01, 2002

Pubmed Data : Intern Med. 2002 May;41(5):345-50. PMID: 12058881
Article Published Date : May 01, 2002
Study Type : Human Study
Additional Links
Diseases : Fatty Liver
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Hepatotoxic
[+]

Tamoxifen treatment increases the risk of endometrial cancer in both premenopausal and postmenopausal women Mar 02, 2005

Pubmed Data : J Natl Cancer Inst. 2005 Mar 2;97(5):375-84. PMID: 15741574
Article Published Date : Mar 02, 2005
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen treatment results in adverse structural and functional changes in the brain in women. Jan 01, 2004

Pubmed Data : Neuroimage. 2004 Jan;21(1):364-71. PMID: 14741674
Article Published Date : Jan 01, 2004
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity , Memory Disorders: Drug-Induced
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Neurotoxic
[+]

Tamoxifen usage is associated with bone loss in patients who continued to menstruate after adjuvant chemotherapy.Feb 01, 2006

Pubmed Data : J Clin Oncol. 2006 Feb 1;24(4):675-80. PMID: 16446340
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Diseases : Osteoporosis
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
[+]

Tamoxifen use is associated with increased risk for endomentrial polyps and cancer.Dec 01, 2005

Pubmed Data : Gynecol Obstet Fertil. 2005 Dec;33(12):975-9. PMID: 16321556
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer, Endometrial Neoplasms
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogen
[+]

The widespread use of tamoxifen as a preventive agent against breast cancer in healthy women may result in significantly elevated levels of endometrial cancer.Sep 09, 2000

Pubmed Data : Lancet. 2000 Sep 9;356(9233):881-7. PMID: 11036892
Article Published Date : Sep 09, 2000
Study Type : Human Study
Additional Links
Diseases : Breast Cancer, Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Women treated with tamoxifen in the adjuvant setting experienced symptoms of sexual dysfunction.May 01, 1999

Pubmed Data : J Clin Oncol. 1999 May;17(5):1488-92. PMID: 10334535
Article Published Date : May 01, 1999
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity , Sexual Dysfunction
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
[+]

Acute pancreatitis caused by tamoxifen-induced severe hypertriglyceridemia after 4 years of tamoxifen use.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACG Case Rep J. 2019 Feb ;6(2):1-3. Epub 2019 Mar 7. PMID: 31157284
Article Published Date : Jan 31, 2019
Study Type : Human: Case Report
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Pancreatitis, Triglycerides: Elevated
Additional Keywords : Risk Factors
Problem Substances : Tamoxifen
[+]

Tamoxifen-induced acute eosinophilic pneumonia in a breast cancer patient.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Surg Case Rep. 2019 ;60:186-190. Epub 2019 Feb 27. PMID: 31229774
Article Published Date : Dec 31, 2018
Study Type : Human: Case Report
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Pneumonia: Drug-Induced, Pneumonia: Eosinophilic
Additional Keywords : Risk Factors
Problem Substances : Tamoxifen
[+]

Carnosic acid cooperates with tamoxifen to induce apoptosis in breast cancer cells.Apr 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 May ;89:827-837. Epub 2017 Mar 6. PMID: 28282784
Article Published Date : Apr 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer, Carnosic Acid, Synergy with Tamoxifen
Problem Substances : Tamoxifen
[+]

Low-dose tamoxifen treatment in juvenile males has long-term adverse effects on the reproductive system.Aug 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Aug 21 ;7(1):8991. Epub 2017 Aug 21. PMID: 28827578
Article Published Date : Aug 20, 2017
Study Type : Animal Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Infertility: Male
Problem Substances : Tamoxifen
[+]

Sesame seeds should be avoided during Tamoxifen therapy. Jun 01, 2007

Pubmed Data : Exp Biol Med (Maywood). 2007 Jun;232(6):754-61. PMID: 17526767
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sesame Seeds
Diseases : Breast Cancer: Conventional Treatment
Additional Keywords : Drug/Natural Substance Contraindications
Problem Substances : Tamoxifen
[+]

Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo.Jun 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lab Anim. 2019 Jun 27:23677219856918. Epub 2019 Jun 27. PMID: 31248325
Article Published Date : Jun 26, 2019
Study Type : Animal Study
Additional Links
Diseases : Abortion: Induced, Chemotherapy-Induced Toxicity: Tamoxifen, Prenatal Chemical Exposures
Additional Keywords : Risk Factors
Problem Substances : Tamoxifen
[+]

Tamoxifen causes DNA damage in multiple organs of adult femaile cynomolgus monkeys.Sep 15, 2003

Pubmed Data : Cancer Res. 2003 Sep 15;63(18):5999-6003. PMID: 14522927
Article Published Date : Sep 15, 2003
Study Type : Animal Study
Additional Links
Diseases : DNA damage
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Genotoxic
[+]

Tamoxifen enhances bladder and liver cancer carcinogenesis in mice exposed to arsenic. Sep 15, 2006

Pubmed Data : Toxicol Appl Pharmacol. 2006 Sep 15;215(3):295-305. Epub 2006 May 18. PMID: 16712894
Article Published Date : Sep 15, 2006
Study Type : Animal Study
Additional Links
Diseases : Arsenic Poisoning, Bladder Cancer, Liver Cancer
Additional Keywords : Drug: Tamoxifen, Drug-Plant-Vitamin Synergies
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen impairs both longitudinal and cortical bone growth in young male rats.Aug 01, 2008

Pubmed Data : J Bone Miner Res. 2008 Aug;23(8):1267-77. PMID: 18348701
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Diseases : Bone Diseases
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia.Apr 01, 2000

Pubmed Data : Carcinogenesis. 2000 Apr;21(4):793-7. PMID: 10753217
Article Published Date : Apr 01, 2000
Study Type : Animal Study
Additional Links
Diseases : Cervical Cancer, Endometrial Cancer, Vaginal Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen is a liver carcinogen in rats.Sep 28, 2001

Pubmed Data : Cancer Lett. 2001 Sep 28;171(1):27-35. PMID: 11485825
Article Published Date : Sep 28, 2001
Study Type : Animal Study
Additional Links
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen metabolites exhibit genotoxic activity.Dec 01, 2001

Pubmed Data : Chem Res Toxicol. 2001 Dec;14(12):1643-53. PMID: 11743747
Article Published Date : Dec 01, 2001
Study Type : Animal Study
Additional Links
Diseases : Breast Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Genotoxic
[+]

Tamoxifen stresses cells of the adult central and peripheral nervous systems and highlights concerns about its clinical and experimental use.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Neuropathol Commun. 2015 ;3(1):74. Epub 2015 Nov 26. PMID: 26610346
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Risk Factors
Problem Substances : Tamoxifen
[+]

Tamoxifen, methotrexate, and 5-fluorouracil inhibits memory acquisition in the animal model. Oct 01, 2011

Pubmed Data : Psychopharmacology (Berl). 2011 Oct ;217(4):539-48. Epub 2011 May 3. PMID: 21537942
Article Published Date : Oct 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Learning disorders, Memory Disorders: Drug-Induced, Memory Loss
Anti Therapeutic Actions : Chemotherapy
Problem Substances : Fluorouracil (5-FU or f5U) , Methotrexate, Tamoxifen
[+]

Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation.Sep 30, 2019

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1 ;317(4):G518-G530. Epub 2019 Aug 1. PMID: 31369292
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Gastrointestinal Inflammation
Problem Substances : Tamoxifen
[+]

The developmental and reproductive toxicity observed in animals given tamoxifen may be due to the oxidative stress it induces.Mar 02, 2001

Pubmed Data : Life Sci. 2001 Mar 2;68(15):1735-49. PMID: 11270620
Article Published Date : Mar 02, 2001
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Oxidant
[+]

The oral administration of delta tocotrienol may be useful in the treatment of Parkinson's disease patients.Oct 29, 2015

Pubmed Data : Neurosci Lett. 2015 Oct 30. Epub 2015 Oct 30. PMID: 26523792
Article Published Date : Oct 29, 2015
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Delta, Vitamin E
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Tamoxifen
[+]

Vitamin C inhibits the inflammation associated ROS that promotes gastric tumorigenesis.Mar 25, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2015 Mar 26. Epub 2015 Mar 26. PMID: 25813526
Article Published Date : Mar 25, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Gastric Cancer, Gastrointestinal Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Tumor, Anticarcinogenic Agents, Antioxidants, Chemopreventive
Additional Keywords : Risk Reduction
Problem Substances : Tamoxifen
[+]

Zinc abrogates anticancer drug tamoxifen-induced hepatotoxicity.Sep 30, 2019

Pubmed Data : Toxicol Mech Methods. 2019 Oct 1:1-9. Epub 2019 Oct 1. PMID: 31532279
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Zinc
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Hepatoprotective
Problem Substances : Tamoxifen
[+]

An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.Mar 31, 2014

Pubmed Data : Crit Rev Toxicol. 2014 Apr ;44(4):348-91. Epub 2014 Feb 4. PMID: 24494825
Article Published Date : Mar 31, 2014
Study Type : Review
Additional Links
Diseases : DNA damage
Additional Keywords : Drug: Tamoxifen
Problem Substances : Aflatoxin, Tamoxifen, Vinyl chloride
Adverse Pharmacological Actions : Carcinogenic, Genotoxic, Mutagenic
[+]

Drugs like amiodarone, tamoxifen, irinotecan, methotrexate, valproic acid and glucocorticoids have been recognized to be associated with steatosis.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2017 Mar ;21(1 Suppl):86-94. PMID: 28379591
Article Published Date : Feb 28, 2017
Study Type : Review
Additional Links
Diseases : Fatty Liver, Liver Damage: Drug-Induced
Additional Keywords : Risk Factors
Problem Substances : Amiodarone, Irinotecan, Methotrexate, Tamoxifen
[+]

EPA may be useful for the treatment of tamoxifen-resistant breast cancer cells with high levels of activated Akt .Jun 30, 2003

Pubmed Data : Ann Oncol. 2003 Jul ;14(7):1051-6. PMID: 12853346
Article Published Date : Jun 30, 2003
Study Type : In Vitro Study
Additional Links
Substances : EPA (Eicosapentaenoic Acid)
Diseases : Breast Cancer, Cancers: Drug Resistant
Additional Keywords : Drug: Tamoxifen, Tamoxifen Resistance
Problem Substances : Tamoxifen
[+]

In vitro and in silico study of Aloe vera leaf extract against human breast cancer.Jan 01, 2019

Pubmed Data : Nat Prod Res. 2019 Jan 2:1-4. Epub 2019 Jan 2. PMID: 30600703
Article Published Date : Jan 01, 2019
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Tamoxifen
[+]

Quercetin Inhibits angiogenesis in tamoxifen-resistant breast cancer cells.Oct 31, 2010

Pubmed Data : Food Chem Toxicol. 2010 Nov ;48(11):3227-34. Epub 2010 Sep 4. PMID: 20804812
Article Published Date : Oct 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Anti-Angiogenic, Antioxidants, Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords : Drug: Tamoxifen, Tamoxifen Resistance
Problem Substances : Tamoxifen
[+]

Resveratrol exhibits anti-cancer properties against tamoxifen-resistant breast cancer cells.Sep 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FASEB J. 2011 Oct ;25(10):3695-707. Epub 2011 Jul 7. PMID: 21737614
Article Published Date : Sep 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Breast Cancer: Drug Resistant
Pharmacological Actions : Estrogen Receptor Modulators, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Tamoxifen Resistance
Problem Substances : Tamoxifen
[+]

Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Theranostics. 2017 ;7(7):1890-1900. Epub 2017 Apr 10. PMID: 28638475
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Endometrial Neoplasms
Problem Substances : Tamoxifen
[+]

Tamoxifen has a proliferative effecct against endometrial cancer cells.Sep 01, 2004

Pubmed Data : Oncol Rep. 2004 Sep;12(3):517-21. PMID: 15289830
Article Published Date : Sep 01, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic, Estrogen Agonist, Proliferative
[+]

Tamoxifen has a proliferative effect in endometrial carcinoma cells.Dec 04, 2016

Pubmed Data : Mol Cell Endocrinol. 2016 Dec 5 ;437:51-61. Epub 2016 Aug 9. PMID: 27519631
Article Published Date : Dec 04, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Endometrial Cancer
Additional Keywords : Increased Risk
Problem Substances : Tamoxifen
[+]

Tamoxifen has both antagonistic and agonistic effects on estrogen receptors, indicating it may have carcinogenic potential in estrogen sensitive cancers.Feb 01, 1997

Pubmed Data : Semin Oncol. 1997 Feb;24(1 Suppl 1):S1-71-S1-80. PMID: 9045319
Article Published Date : Feb 01, 1997
Study Type : Review
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Estrogenic
[+]

Tamoxifen induces lesions in endometrial tissues associated with DNA damage and cancer.May 01, 1999

Pubmed Data : Cancer Res. 1999 May 1;59(9):2091-5. PMID: 10232593
Article Published Date : May 01, 1999
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic, Genotoxic, Mutagenic
[+]

Tamoxifen is a carcinogen in the human uterus and rat liver.May 01, 2004

Pubmed Data : Cancer Res. 2004 May 1;64(9):3144-7. PMID: 15126352
Article Published Date : May 01, 2004
Study Type : Commentary
Additional Links
Diseases : DNA damage, Endometrial Cancer, Uterine Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen may induce endometrial cancer.Jan 01, 2006

Pubmed Data : Ann Ist Super Sanita. 2006;42(2):170-3. PMID: 17033137
Article Published Date : Jan 01, 2006
Study Type : Review
Additional Links
Diseases : Endometrial Cancer
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Carcinogenic
[+]

Tamoxifen may induce non-alcoholic fatty liver.Jan 01, 2007

Pubmed Data : Expert Opin Drug Saf. 2007 Jan;6(1):1-4. PMID: 17181445
Article Published Date : Jan 01, 2007
Study Type : Review
Additional Links
Diseases : Chemically-Induced Liver Damage, Fatty Liver
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
[+]

Tamoxifen metabolism could be severely altered by several antidepressants.Mar 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ment Illn. 2019 Mar 22 ;11(1):8115. Epub 2019 Jun 11. PMID: 31281608
Article Published Date : Mar 21, 2019
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer
Problem Substances : Antidepressants, Tamoxifen
[+]

Tamoxifen-dependent induction of AGR2 is associated with increased aggressiveness of endometrial cancer cells.Apr 11, 2017

Pubmed Data : Cancer Invest. 2017 Apr 12:1-12. Epub 2017 Apr 12. PMID: 28402678
Article Published Date : Apr 11, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Tamoxifen, Endometrial Cancer
Additional Keywords : Increased Risk
Problem Substances : Tamoxifen
[+]

There are a number of natural and synthetic chemicals with tumor-inducing effects.Oct 01, 2005

Pubmed Data : Discov Med. 2005 Oct;5(29):472-7. PMID: 20704845
Article Published Date : Oct 01, 2005
Study Type : Commentary
Additional Links
Diseases : Tumors
Problem Substances : Aflatoxin, Aromatic hydrocarbons, Cadmium, Dioxins, Estrogen Receptor Agonists, Lead, N-Nitrosamines, Nickelous acetate, Nickelous Sulfate, Polycyclic aromatic hydrocarbon, Tamoxifen, Vinyl chloride
Adverse Pharmacological Actions : Tumorigenic
[+]

This review analyses plausible mechanisms of Punica in preventing the progression of breast cancer by acting at various steps of carcinogenesis.Apr 08, 2015

Pubmed Data : Biofactors. 2015 Apr 9. Epub 2015 Apr 9. PMID: 25857627
Article Published Date : Apr 08, 2015
Study Type : Review
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer, Breast Cancer: Estrogen, Breast Cancer: Metastatic
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Chemopreventive, Chemotherapeutic
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Tamoxifen
[+]

This study provided a possible support that the exposure of BPA in environmental media may potentially induce TAM resistance to breast cancer treatment.Nov 21, 2018

Pubmed Data : Environ Sci Pollut Res Int. 2018 Nov 22. Epub 2018 Nov 22. PMID: 30467747
Article Published Date : Nov 21, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Bisphenol Toxicity, Breast Cancer
Problem Substances : Bisphenol A , Tamoxifen
[+]

Tualang honey may be a potential adjuvant to be used with TAM for reducing the dose of TAM and reducing TAM-induced adverse effects.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:989841. Epub 2013 Feb 13. PMID: 23476711
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Tualang Honey
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Chemotherapy-Induced Toxicity: Tamoxifen
Pharmacological Actions : Apoptotic, Chemoprotective Agents
Problem Substances : Tamoxifen
[+]

Unlike tamoxifen and estradiol pomegranate exerts selective estrogen receptor modulator activity without uterotrophic properties.Aug 10, 2011

Pubmed Data : J Nutr Biochem. 2011 Aug 10. Epub 2011 Aug 10. PMID: 21839626
Article Published Date : Aug 10, 2011
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate
Diseases : Estrogen Deficiency, Estrogen Dominance
Pharmacological Actions : Selective estrogen enzyme modulator (SEEM)
Additional Keywords : HRT Alternatives, Superiority of Natural Substances versus Drugs
Problem Substances : 17beta-estradiol, Tamoxifen
Adverse Pharmacological Actions : Uterotrophic

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