Thyroxine

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21 Diseases Researched for Thyroxine
NameACCKFocus
Hypothyroidism981Locked
Hypoglycemia220Locked
Liver Disease220Locked
Venous Thrombosis220Locked
Drug-Induced Toxicity: L-Thyroxine414Locked
Blood Coagulation Disorders110Locked
Bone Fractures110Locked
Deep Vein Thrombosis110Locked
Delerium: Acute110Locked
Drug-Induced Toxicity 110Locked
Fibrinogen: Elevated110Locked
Overweight 110Locked
Thrombosis110Locked
Oxidative Stress35Locked
Hyperthyroidism23Locked
Thyroid Cancer23Locked
Cardiovascular Diseases11Locked
DNA damage11Locked
Dyslipidemias11Locked
Lipid Peroxidation11Locked
Osteoporosis11Locked
2 Adverse Pharmacological Actions Researched for Thyroxine
NameACCKFocus
Oxidant35Locked
Nephrotoxic12Locked

View the Evidence:
26 Abstracts with Thyroxine Research

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"Levothyroxine Medication is Associated with Adiposity Independent of TSH.May 25, 2012

Pubmed Data : Exp Clin Endocrinol Diabetes. 2012 May 25. Epub 2012 May 25. PMID: 22639395
Article Published Date : May 25, 2012
Study Type : Human Study
Additional Links
Diseases : Overweight
Problem Substances : Levothyroxine
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Among adults aged 70 or more, current levothyroxine treatment was associated with a significantly increased risk of fracture, with a strong dose-response relation. Jan 01, 2011

Pubmed Data : BMJ. 2011;342:d2238. Epub 2011 Apr 28. PMID: 21527461
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Bone Fractures
Problem Substances : Levothyroxine
[+]

Bisphosphonates are less effective in women receiving TSH-suppressing doses of thyroxine.May 01, 2009

Pubmed Data : Thyroid. 2009 May;19(5):437-42. PMID: 19415993
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: L-Thyroxine
Problem Substances : Alendronate (trade name Fosamax) , Thyroxine
[+]

Desiccated thyroid extract compares favorably with levothyroxine in the treatment of hypothyroidism.Apr 30, 2013

Pubmed Data : J Clin Endocrinol Metab. 2013 May ;98(5):1982-90. Epub 2013 Mar 28. PMID: 23539727
Article Published Date : Apr 30, 2013
Study Type : Human Study
Additional Links
Substances : Thyroid Extract
Diseases : Hypothyroidism
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Levothyroxine
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Dessicated thyroid (Armour) has been associated with superior clinical outcomes compared to levothyroxine in the treatment of hypothyroidism. Jun 01, 2004

Pubmed Data : Altern Med Rev. 2004 Jun;9(2):157-79. PMID: 15253676
Article Published Date : Jun 01, 2004
Study Type : Human Study
Additional Links
Substances : Thyroid Extract
Diseases : Hypothyroidism
Additional Keywords : Superiority of Natural Substances versus Drugs
Problem Substances : Levothyroxine
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Exercise intensity and its effects on thyroid hormones.Nov 30, 2005

Pubmed Data : Neuro Endocrinol Lett. 2005 Dec ;26(6):830-4. PMID: 16380698
Article Published Date : Nov 30, 2005
Study Type : Human Study
Additional Links
Problem Substances : Thyroxine
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In hypothyroid patients L-T4-replacement, that is sufficient to maintain a normal serum TSH, is accompanied by a serum free T4 that is higher than that in untreated euthyroid patients or normal individuals and may not result in an appropriately normal serFeb 01, 2002

Pubmed Data : J Endocrinol Invest. 2002 Feb ;25(2):106-9. PMID: 11929079
Article Published Date : Feb 01, 2002
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism
Problem Substances : Levothyroxine
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Increasing levels of free thyroxine as a risk factor for a first venous thrombosis.Jun 03, 2010

Pubmed Data : Blood. 2010 Jun 3;115(22):4344-9. Epub 2010 Mar 22. PMID: 20308594
Article Published Date : Jun 03, 2010
Study Type : Human Study
Additional Links
Diseases : Venous Thrombosis
Problem Substances : Thyroxine
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Levothyroxine administration is associated with altered fibrinolysis and coagulation, indicating it may increase the risk of venous thrombosis. Jul 05, 2011

Pubmed Data : J Thromb Haemost. 2011 Jul 5. Epub 2011 Jul 5. PMID: 21729238
Article Published Date : Jul 05, 2011
Study Type : Human Study
Additional Links
Diseases : Deep Vein Thrombosis, Thrombosis, Venous Thrombosis
Problem Substances : Levothyroxine
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Levothyroxine may be a risk factor for hypoglycaemia in patients with liver disease.Oct 01, 2003

Pubmed Data : J Clin Pharm Ther. 2003 Oct;28(5):355-61. PMID: 14632959
Article Published Date : Oct 01, 2003
Study Type : Human Study
Additional Links
Diseases : Hypoglycemia, Hypothyroidism, Liver Disease
Additional Keywords : Diseases that are Linked
Problem Substances : Levothyroxine
[+]

Levothyroxine replacement therapy increases coagulation (fibrinogen) following initiation of treatment.May 01, 2005

Pubmed Data : J Endocrinol Invest. 2005 May;28(5):398-404. PMID: 16075920
Article Published Date : May 01, 2005
Study Type : Human Study
Additional Links
Diseases : Blood Coagulation Disorders, Drug-Induced Toxicity , Fibrinogen: Elevated, Hypothyroidism
Problem Substances : Levothyroxine
[+]

Levothyroxine use is associated with increased risk of hypoglycemia in patients with liver impairment.Jan 01, 2008

Pubmed Data : Int J Clin Pharmacol Ther. 2008 Jan;46(1):1-13. PMID: 18218292
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Diseases : Hypoglycemia, Hypothyroidism, Liver Disease
Problem Substances : Levothyroxine
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Pycnogenol prevents oxidative stress and side effects in patients with hypothyroidism during levothyroxine treatment.May 31, 2019

Pubmed Data : Minerva Endocrinol. 2019 Jun ;44(2):199-204. PMID: 31099529
Article Published Date : May 31, 2019
Study Type : Human Study
Additional Links
Substances : Pycnogenol (Pine Bark)
Diseases : Hypothyroidism
Problem Substances : Levothyroxine
[+]

Thyroid hormone replacement therapy may result in acute delerium in patients with primary hypothyroidism. Sep 01, 2005

Pubmed Data : Thyroid. 2005 Sep;15(9):1099-101. PMID: 16187922
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Delerium: Acute, Hypothyroidism
Problem Substances : Levothyroxine
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L-thyroxine increases oxidative stress in rat renal cortex.Feb 01, 2011

Pubmed Data : Mol Biol Rep. 2011 Feb;38(2):1047-54. Epub 2010 Jun 24. PMID: 20574713
Article Published Date : Feb 01, 2011
Study Type : Animal Study
Additional Links
Problem Substances : Thyroxine
Adverse Pharmacological Actions : Nephrotoxic
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L-thyroxine induces enhanced oxidative stress and oxygen consumption in the hyperthyroid rat liver.May 28, 2008

Pubmed Data : Chem Biol Interact. 2008 May 28;173(2):105-14. Epub 2008 Mar 10. PMID: 18377885
Article Published Date : May 28, 2008
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress
Problem Substances : Thyroxine
Adverse Pharmacological Actions : Oxidant
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L-thyroxine induces oxidative stress in the rat testicle.Nov 25, 2008

Pubmed Data : Chem Biol Interact. 2008 Nov 25;176(2-3):121-8. Epub 2008 Aug 3. PMID: 18723006
Article Published Date : Nov 25, 2008
Study Type : Animal Study
Additional Links
Diseases : Drug-Induced Toxicity: L-Thyroxine, Oxidative Stress
Problem Substances : Thyroxine
Adverse Pharmacological Actions : Oxidant
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P. oleracea extract has a protective effect on cardiac dysfunction due to subclinical hyperthyroidism induced by levothyroxine sodium in rats.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2018 Mar-Apr;8(2):161-169. PMID: 29632847
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Purslane, Vitamin C
Diseases : Hyperthyroidism
Pharmacological Actions : Cardioprotective, Malondialdehyde Down-regulation
Problem Substances : Levothyroxine
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Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat.Dec 31, 1990

Pubmed Data : Toxicol Pathol. 1991 ;19(3):197-205. PMID: 1780636
Article Published Date : Dec 31, 1990
Study Type : Animal Study
Additional Links
Diseases : Thyroid Cancer
Problem Substances : Lovastatin, Simvastatin, Statin Drugs, Thyroxine
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Synthetic thyroxine products are below 100% purity. Sep 01, 2010

Pubmed Data : Arch Pharm Res. 2010 Sep;33(9):1419-23. Epub 2010 Oct 14. PMID: 20945141
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Problem Substances : D-Thyroxine, Levothyroxine
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Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.May 05, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2011 May 6 ;286(18):16163-73. Epub 2011 Feb 16. PMID: 21325280
Article Published Date : May 05, 2011
Study Type : In Vitro Study
Additional Links
Additional Keywords : Thyroxine Conformation
Problem Substances : Thyroxine
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Dry olive leaf extract was efficient in reducing DNA damage induced by thyroxine at all tested concentrations usedDec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2015 ;2015:762192. Epub 2015 Feb 19. PMID: 25789081
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Olive leaf extract
Diseases : DNA damage, Drug-Induced Toxicity: L-Thyroxine
Pharmacological Actions : Antioxidants, Genoprotective
Problem Substances : Thyroxine
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Review: Thyroid hormone-induced oxidative stress.Feb 01, 2006

Pubmed Data : Cell Mol Life Sci. 2006 Feb;63(4):414-34. PMID: 16389448
Article Published Date : Feb 01, 2006
Study Type : Review
Additional Links
Diseases : Drug-Induced Toxicity: L-Thyroxine, Hyperthyroidism, Lipid Peroxidation, Oxidative Stress
Problem Substances : Thyroxine
Adverse Pharmacological Actions : Oxidant
[+]

Subclinical thyroid disease.Mar 23, 2012

Pubmed Data : Lancet. 2012 Mar 24 ;379(9821):1142-54. Epub 2012 Jan 23. PMID: 22273398
Article Published Date : Mar 23, 2012
Study Type : Review
Additional Links
Diseases : Cardiovascular Diseases, Dyslipidemias, Hypothyroidism, Osteoporosis
Problem Substances : Thyroxine
[+]

Thyroid hormonal responses to intensive interval versus steady-state endurance exercise sessions.Dec 31, 2011

Pubmed Data : Hormones (Athens). 2012 Jan-Mar;11(1):54-60. PMID: 22450344
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Problem Substances : Thyroxine
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TSH suppression therapy with thyroxine replacement does not significantly improve the condition of those with low-risk thyroid cancer.Nov 01, 2005

Pubmed Data : Nat Clin Pract Endocrinol Metab. 2005 Nov;1(1):32-40. PMID: 16929364
Article Published Date : Nov 01, 2005
Study Type : Review
Additional Links
Diseases : Thyroid Cancer
Problem Substances : Thyroxine

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