Titanium Dioxide

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30 Diseases Researched for Titanium Dioxide
NameACCKFocus
Titanium Toxicity815Locked
Chemical Exposure212Locked
DNA damage811Locked
Chemically-Induced Liver Damage36Locked
Oxidative Stress36Locked
Anxiety12Locked
Arthritis12Locked
Bisphenol Toxicity12Locked
Cardiovascular Diseases12Locked
Depression12Locked
Dysbiosis12Locked
Gastrointestinal Inflammation12Locked
High Fructose Diet12Locked
Infertility: Female12Locked
Infertility: Male12Locked
Kidney Damage12Locked
Kidney Damage: Chemically-Induced12Locked
Lipid Peroxidation12Locked
Liver Damage12Locked
Low Testosterone12Locked
Lung Damage12Locked
Lung Injury: Acute12Locked
Metabolic Diseases12Locked
Microplastic Toxicity12Locked
Testicular Injury: Chemical/Metal Induced12Locked
Fibrosarcoma11Locked
Gastric Cancer11Locked
Inflammation11Locked
Skin Cancer11Locked
Tumors11Locked
7 Adverse Pharmacological Actions Researched for Titanium Dioxide
NameACCKFocus
Bioaccumulator110Locked
Cytotoxic46Locked
Gastrotoxic24Locked
Carcinogenic33Locked
Inflammatory23Locked
Oxidant12Locked
Genotoxic11Locked

View the Evidence:
39 Abstracts with Titanium Dioxide Research

[+]

Oral administration of titanium dioxide results in gastro-intestinal absorption and increases in blood levels. Feb 01, 2000

Pubmed Data : Pharmazie. 2000 Feb;55(2):140-3. PMID: 10723775
Article Published Date : Feb 01, 2000
Study Type : Human Study
Additional Links
Anti Therapeutic Actions : Nanotechnology
Problem Substances : Titanium Dioxide
[+]

Topical microfine titanium dioxide from sunscreens is capable of accumulating in the epidermis and dermis of humans subjects.Nov 01, 1996

Pubmed Data : Australas J Dermatol. 1996 Nov;37(4):185-7. PMID: 8961584
Article Published Date : Nov 01, 1996
Study Type : Human Study
Additional Links
Diseases : Chemical Exposure
Anti Therapeutic Actions : Nanotechnology
Problem Substances : Sunscreen, Titanium Dioxide
Adverse Pharmacological Actions : Bioaccumulator
[+]

Alleviative effect of lactoferrin interventions against the hepatotoxicity induced by titanium dioxide nanoparticles.May 15, 2023

Pubmed Data : Biol Trace Elem Res. 2023 May 16. Epub 2023 May 16. PMID: 37191759
Article Published Date : May 15, 2023
Study Type : Animal Study
Additional Links
Substances : Lactoferrin
Diseases : Chemically-Induced Liver Damage, Titanium Toxicity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Titanium Dioxide, Titanium Nanoparticles
[+]

Acute exposure to sunscreen containing titanium induces an adaptive response and oxidative stress in Mytillus galloprovincialis.Feb 28, 2018

Pubmed Data : Ecotoxicol Environ Saf. 2018 Mar ;149:58-63. Epub 2017 Nov 15. PMID: 29154135
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Diseases : Lipid Peroxidation, Oxidative Stress
Additional Keywords : Environmental Pollution, Lipid Peroxidation, oxidative stress, Sunscreen, Titanium Dioxide
Problem Substances : Sunscreen, Titanium Dioxide
[+]

Adverse effects of titanium dioxide nanoparticles on beneficial gut bacteria.Jun 30, 2023

Pubmed Data : Environ Res. 2023 Jul 1 ;228:115921. Epub 2023 Apr 15. PMID: 37068726
Article Published Date : Jun 30, 2023
Study Type : Animal Study
Additional Links
Diseases : Titanium Toxicity
Problem Substances : Titanium Dioxide
Adverse Pharmacological Actions : Gastrotoxic
[+]

Ameliorative effects of thymoquinone on titanium dioxide nanoparticles induced acute toxicity.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Vet Sci Med. 2018 Jun ;6(1):16-21. Epub 2018 Feb 23. PMID: 30255073
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Titanium Toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Titanium Dioxide, Titanium Nanoparticles
[+]

Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A.Nov 26, 2017

Pubmed Data : Environ Pollut. 2017 Nov 27 ;234:307-317. Epub 2017 Nov 27. PMID: 29190539
Article Published Date : Nov 26, 2017
Study Type : Animal Study
Additional Links
Diseases : Bisphenol Toxicity, Dysbiosis, Titanium Toxicity
Problem Substances : Bisphenol A , Titanium Dioxide
[+]

Eugenol attenuates TiO 2 nanoparticles-induced oxidative damage, biochemical toxicity and DNA damage.Jan 08, 2021

Pubmed Data : Environ Sci Pollut Res Int. 2021 Jan 9. Epub 2021 Jan 9. PMID: 33420693
Article Published Date : Jan 08, 2021
Study Type : Animal Study
Additional Links
Substances : Eugenol
Diseases : DNA damage
Pharmacological Actions : Antioxidants
Problem Substances : Titanium Dioxide
[+]

Ginkgo biloba extract reverses the renal effects of titanium dioxide nanoparticles in adult male rats.Dec 31, 2015

Pubmed Data : Biochem Res Int. 2016 ;2016:5781579. Epub 2016 Mar 3. PMID: 27042354
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Renoprotective
Additional Keywords : Plant Extracts
Problem Substances : Titanium Dioxide, Titanium Nanoparticles
[+]

Grape seed proanthocyanidin extract mitigates titanium dioxide nanoparticle-induced hepatotoxicity.Nov 06, 2019

Pubmed Data : Biol Trace Elem Res. 2019 Nov 7. Epub 2019 Nov 7. PMID: 31701464
Article Published Date : Nov 06, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Proanthocyanidins
Problem Substances : Titanium Dioxide, Titanium Nanoparticles
[+]

Grape seed procyanidin extract can protect against the toxicity of titanium dioxide nanoparticles.Sep 24, 2017

Pubmed Data : Chem Biol Interact. 2017 Sep 25 ;275:133-144. Epub 2017 Aug 2. PMID: 28780322
Article Published Date : Sep 24, 2017
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : DNA damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 inducer, Malondialdehyde Down-regulation, Nrf2 activation
Additional Keywords : Proanthocyanidins
Problem Substances : Titanium Dioxide
[+]

Lactobacillus rhamnosus GG recovered the gut dysbiosis and decreased the abundance of inflammation-related bacteria from titanium dioxide nanoparticles.Aug 31, 2021

Pubmed Data : J Agric Food Chem. 2021 Sep 1 ;69(34):9788-9799. Epub 2021 Aug 12. PMID: 34382390
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus GG
Diseases : Chemically-Induced Liver Damage, Gastrointestinal Inflammation, High Fructose Diet, Metabolic Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Prophylactic Agents
Problem Substances : Titanium Dioxide
[+]

Lycopene alleviates titanium dioxide nanoparticle-induced testicular toxicity.Aug 15, 2021

Pubmed Data : Biol Trace Elem Res. 2021 Aug 16. Epub 2021 Aug 16. PMID: 34396458
Article Published Date : Aug 15, 2021
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Problem Substances : Titanium Dioxide
[+]

Naringenin mitigates titanium dioxide induced chronic arthritis.Nov 30, 2018

Pubmed Data : Inflamm Res. 2018 Dec ;67(11-12):997-1012. Epub 2018 Oct 28. PMID: 30370484
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Problem Substances : Titanium Dioxide
[+]

Oral administration of titanium dioxide nanoparticles cause liver and heart injury, and wide distribution in the liver, spleen, kidneys and lung tissue. Jan 30, 2007

Pubmed Data : Toxicol Lett. 2007 Jan 30;168(2):176-85. Epub 2006 Dec 9. PMID: 17197136
Article Published Date : Jan 30, 2007
Study Type : Animal Study
Additional Links
Diseases : Cardiovascular Diseases, Chemical Exposure, Liver Damage
Problem Substances : Titanium Dioxide
Adverse Pharmacological Actions : Cytotoxic
[+]

Oral exposure to food grade titanium dioxide (E171) induces intestinal and behavioural alterations in adult mice.Feb 04, 2024

Pubmed Data : J Trace Elem Med Biol. 2024 Feb 5 ;83:127409. Epub 2024 Feb 5. PMID: 38394968
Article Published Date : Feb 04, 2024
Study Type : Animal Study
Additional Links
Diseases : Anxiety, Depression
Problem Substances : Titanium Dioxide
Adverse Pharmacological Actions : Gastrotoxic
[+]

Quercetin mitigates oxidative stress, inflammation, apoptosis, and histopathological alterations induced by chronic titanium dioxide nanoparticle exposure.Aug 15, 2023

Pubmed Data : Microsc Microanal. 2023 Aug 16. Epub 2023 Aug 16. PMID: 37584520
Article Published Date : Aug 15, 2023
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Titanium Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Problem Substances : Titanium Dioxide
[+]

Sunscreens as a source of hydrogen peroxide production in coastal waters.Aug 18, 2014

Pubmed Data : Environ Sci Technol. 2014 Aug 19 ;48(16):9037-42. Epub 2014 Aug 1. PMID: 25069004
Article Published Date : Aug 18, 2014
Study Type : Environmental
Additional Links
Additional Keywords : Environmental Pollution
Problem Substances : Sunscreen, Titanium Dioxide
[+]

Thymoquinone and avenanthramides have antioxidative and anti-inflammatory effect against the detrimental effect of titanium dioxide naonparticles.Dec 31, 2016

Pubmed Data : Pathol Res Pract. 2017 Jan ;213(1):13-22. Epub 2016 Aug 9. PMID: 27916297
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Oats, Thymoquinone
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Problem Substances : Titanium Dioxide, Titanium Nanoparticles
[+]

Tinospora cordifolia ameliorated titanium dioxide nanoparticle-induced toxicity.Jan 31, 2021

Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2021 Feb ;240:108908. Epub 2020 Oct 3. PMID: 33022381
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Substances : Guduchi
Diseases : Titanium Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Nrf2 activation, Postaglandin PGE2 downregulation
Problem Substances : Titanium Dioxide, Titanium Nanoparticles
[+]

TiO2 nanoparticles combined with polystyrene nanoplastics aggravated reproductive toxicity in female mice.Sep 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Sci Food Agric. 2023 Oct ;103(13):6452-6462. Epub 2023 Jun 7. PMID: 37209239
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Diseases : Infertility: Female, Microplastic Toxicity
Additional Keywords : Synergistic Toxicity
Problem Substances : Polystyrene nanoparticles, Titanium Dioxide
[+]

Titanium dioxide causes oxidative stress responses in the water flea (Daphnia magna) in a particle-size dependent fashion. Feb 13, 2010

Pubmed Data : Sci Total Environ. 2010 Feb 13. Epub 2010 Feb 13. PMID: 20153877
Article Published Date : Feb 13, 2010
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress
Problem Substances : Titanium Dioxide
Adverse Pharmacological Actions : Oxidant
[+]

Titanium dioxide nanoparticles are readily absorbed in mice and accumulate in the liver for extended durations. Aug 01, 2008

Pubmed Data : J Toxicol Sci. 2008 Aug;33(3):293-8. PMID: 18670160
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Problem Substances : Titanium Dioxide
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Titanium dioxide nanoparticles cause acute toxicity, thrombosis, liver, lung and kidney damage when injected into mice. May 01, 2009

Pubmed Data : J Appl Toxicol. 2009 May;29(4):330-7. PMID: 19156710
Article Published Date : May 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Kidney Damage, Lung Damage
Anti Therapeutic Actions : Nanotechnology
Problem Substances : Titanium Dioxide
Adverse Pharmacological Actions : Cytotoxic
[+]

Titanium dioxide nanoparticles contribute to pulmonary inflammation after intraperitoneal administration in lungs of mice. Jan 01, 2010

Pubmed Data : J Toxicol Environ Health A. 2010 Jan;73(5):396-409. PMID: 20155581
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Lung Injury: Acute
Anti Therapeutic Actions : Nanotechnology
Problem Substances : Titanium Dioxide
Adverse Pharmacological Actions : Inflammatory
[+]

Titanium dioxide nanoparticles could change stereological and morphometrical parameters of the seminiferous tubules.Dec 31, 2015

Pubmed Data : Bratisl Lek Listy. 2016 ;117(11):659-664. PMID: 28125892
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Infertility: Male, Low Testosterone, Titanium Toxicity
Problem Substances : Titanium Dioxide, Titanium Nanoparticles
[+]

Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice.Nov 15, 2009

Pubmed Data : Cancer Res. 2009 Nov 15;69(22):8784-9. Epub 2009 Nov 3. PMID: 19887611
Article Published Date : Nov 15, 2009
Study Type : Animal Study
Additional Links
Diseases : DNA damage
Problem Substances : Titanium Dioxide
[+]

Antioxidant thymoquinone and eugenol alleviate TiO 2 nanoparticle-induced toxicity in human blood cells.Jul 18, 2021

Pubmed Data : Toxicol Mech Methods. 2021 Jul 19:1-11. Epub 2021 Jul 19. PMID: 34219618
Article Published Date : Jul 18, 2021
Study Type : In Vitro Study
Additional Links
Substances : Eugenol, Thymoquinone
Diseases : Titanium Toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Titanium Dioxide, Titanium Nanoparticles
[+]

Carcinogenic effects of titanium dioxide nanoparticles in human gastric epithelial cells in vitro.Aug 22, 2013

Pubmed Data : Biomed Pharmacother. 2013 Aug 23. Epub 2013 Aug 23. PMID: 24051123
Article Published Date : Aug 22, 2013
Study Type : In Vitro Study
Additional Links
Diseases : Gastric Cancer
Anti Therapeutic Actions : Nanotechnology
Problem Substances : Nanoparticles, Titanium Dioxide, Titanium Nanoparticles
Adverse Pharmacological Actions : Carcinogenic
[+]

Exposure to titanium dioxide nanomaterials provokes inflammation. Sep 22, 2009

Pubmed Data : ACS Nano. 2009 Sep 22;3(9):2523-32. PMID: 19769402
Article Published Date : Sep 22, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Inflammation
Problem Substances : Titanium Dioxide
Adverse Pharmacological Actions : Inflammatory
[+]

Nanoparticle sunscreens may have photocarcinogenic potential. Feb 01, 2011

Pubmed Data : Australas J Dermatol. 2011 Feb;52(1):1-6. Epub 2010 Aug 16. PMID: 21332685
Article Published Date : Feb 01, 2011
Study Type : Review
Additional Links
Diseases : Skin Cancer
Anti Therapeutic Actions : Nanotechnology
Problem Substances : Nanoparticles, Sunscreen, Titanium Dioxide
Adverse Pharmacological Actions : Carcinogenic
[+]

Nanoparticle zinc oxide and titanium dioxide exhibit genotoxicity and cytotoxicity.Oct 01, 2010

Pubmed Data : Nanomedicine (Lond). 2010 Oct;5(8):1193-203. PMID: 21039197
Article Published Date : Oct 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Anti Therapeutic Actions : Nanotechnology
Problem Substances : Titanium Dioxide, Zinc Oxide
Adverse Pharmacological Actions : Genotoxic
[+]

These data support the antioxidant properties' nutraceutical role of Moringa oleifera against titanium dioxide nanoparticles-induced toxicity.May 03, 2018

Pubmed Data : Biol Trace Elem Res. 2018 May 4. Epub 2018 May 4. PMID: 29728821
Article Published Date : May 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : Moringa oleifera
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Titanium Dioxide, Titanium Nanoparticles
[+]

Titanium dioxide nanoparticles convert benign mouse fibrosarcoma cells into aggressive tumor cells.Nov 01, 2009

Pubmed Data : Am J Pathol. 2009 Nov;175(5):2171-83. Epub 2009 Oct 8. PMID: 19815711
Article Published Date : Nov 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Fibrosarcoma, Tumors
Problem Substances : Titanium Dioxide
Adverse Pharmacological Actions : Carcinogenic
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Titanium dioxide nanoparticles exhibit cytotoxicity in mouse epidermal cells. Jan 01, 2009

Pubmed Data : J Toxicol Environ Health A. 2009;72(19):1141-9. PMID: 20077182
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Problem Substances : Titanium Dioxide
Adverse Pharmacological Actions : Cytotoxic
[+]

Titanium dioxide nanoparticles have genotoxic and cytotoxic potential in fish cells.Jul 01, 2008

Pubmed Data : Ecotoxicology. 2008 Jul;17(5):410-20. Epub 2008 May 20. PMID: 18491228
Article Published Date : Jul 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Titanium Dioxide
Adverse Pharmacological Actions : Cytotoxic
[+]

Titanium dioxide nanoparticles have genotoxic effects. Jun 01, 2009

Pubmed Data : Hum Exp Toxicol. 2009 Jun;28(6-7):339-52. PMID: 19755445
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Titanium Dioxide
[+]

Titanium dioxide nanoparticles induce oxidative damage in human bronchial epithelial cells. Sep 15, 2005

Pubmed Data : Toxicology. 2005 Sep 15;213(1-2):66-73. PMID: 15970370
Article Published Date : Sep 15, 2005
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Titanium Dioxide
[+]

Titanium dioxide nanoparticles trigger a damage response in peripheral blood lymphocytes.Jun 01, 2008

Pubmed Data : Environ Mol Mutagen. 2008 Jun;49(5):399-405. PMID: 18418868
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Titanium Dioxide

Titanium Dioxide Related Articles

MSG: Delicious Seasoning Or Drug And Poison?
Written by Sayer Ji, Founder
Monosodium glutamate (MSG) is a commonly used "flavor enhancer," and so powerfully so that (arguably) you could spray it on roadkill and it would taste good. This omnipresent ingredient in modern mass market food takes advantage of our biologically hard-wired taste receptors, and makes it very hard to stop eating the foods "seasoned" with this ingredient.
Nanoparticle titanium dioxide is a clearly toxic mineral which can be found as an additive and excipient in various foods, cosmetics, vitamins and drugs. Over 4 million tons of this pigmentary substance is consumed annually worldwide, making its way into such FDA-approved applications as skim milk. It does not have to be listed in the ingredient list because it is considered a "manufacturing aid."

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