Tylenol

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58 Diseases Researched for Tylenol
NameACCKFocus
Acetaminophen (Tylenol) Toxicity 269678Locked
Liver Damage: Drug-Induced99194Locked
Prenatal Chemical Exposures22117Locked
Oxidative Stress5096Locked
Chemically-Induced Liver Damage4285Locked
Fever260Locked
Attention Deficit Disorder with Hyperactivity652Locked
Autism Spectrum Disorders734Locked
Kidney Damage: Drug-Induced1326Locked
Inflammation823Locked
Drug-Induced Toxicity 120Locked
Febrile Seizures120Locked
Hearing Loss120Locked
Hypersensitivity120Locked
Neurodevelopmental Disorders313Locked
Attention Deficit Hyperactivity Disorder110Locked
Blood Transfusion110Locked
Cardiac Mortality 110Locked
Children: Drug-Induced Toxicity110Locked
Chronic Pain110Locked
Cold and Flu: Infants & Children 110Locked
Common Cold110Locked
Dyspepsia110Locked
Gastrointestinal Diseases110Locked
Infant Mortality 110Locked
Leukemia: Chronic Lymphocytic Leukemia (CLL)110Locked
Lipid Peroxidation510Locked
Lymphoma110Locked
Migraine Disorders110Locked
Rhinovirus Infection 110Locked
Kidney Damage: Chemically-Induced36Locked
Liver Damage46Locked
Infertility: Female24Locked
Mitochondrial Dysfunction 24Locked
Testicular Injury: Chemical/Metal Induced24Locked
Liver Failure: Drug Induced13Locked
Alcohol Toxicity 12Locked
Asthma12Locked
Chemotherapy-Induced Toxicity: Cisplatin12Locked
DNA damage12Locked
Fetal Origin of Adult Disease12Locked
Gastric Ulcer12Locked
Glutathione Deficiency 12Locked
Ibuprofen Toxicity12Locked
Infertility: Male12Locked
Liver Disease12Locked
Lung Inflammation12Locked
Male Reproductive Development Abnormalities12Locked
Sexual Behavior12Locked
Uranium Poisoning12Locked
Anemia11Locked
Autism11Locked
Cervical Cancer11Locked
Endocannabinoid Disorders11Locked
Endometrial Cancer11Locked
Endometrial Neoplasms11Locked
Liver Cancer11Locked
Neurodegenerative Diseases11Locked
11 Adverse Pharmacological Actions Researched for Tylenol
NameACCKFocus
Neurotoxic614Locked
Nephrotoxic212Locked
Carcinogenic110Locked
Immunosuppressive110Locked
Hepatotoxic36Locked
Cytotoxic15Locked
Immunotoxic12Locked
Oxidant12Locked
Genotoxic11Locked
Mutagenic11Locked
Necrotic11Locked
Related Topics

Tylenol is a Sub of the following Topic

View the Evidence:
434 Abstracts with Tylenol Research

[+]

Acetaminophen use and the risk of asthma in children and adults.Oct 31, 2009

Pubmed Data : Chest. 2009 Nov ;136(5):1316-1323. Epub 2009 Aug 20. PMID: 19696122
Article Published Date : Oct 31, 2009
Study Type : Meta Analysis, Review
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal paracetamol use and asthma in childhood: A systematic review and meta-analysis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Allergol Immunopathol (Madr). 2017 ;45(6):528-533. Epub 2017 Feb 22. PMID: 28237129
Article Published Date : Dec 31, 2016
Study Type : Meta Analysis, Review
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

The use of paracetamol during pregnancy is associated with an increased risk of childhood asthma.Mar 31, 2011

Pubmed Data : Clin Exp Allergy. 2011 Apr ;41(4):482-9. Epub 2011 Feb 22. PMID: 21338428
Article Published Date : Mar 31, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Prevalence of hypersensitivity reactions in children associated with acetaminophen.Dec 31, 2017

Pubmed Data : Int Arch Allergy Immunol. 2018 ;176(2):106-114. Epub 2018 Apr 3. PMID: 29614487
Article Published Date : Dec 31, 2017
Study Type : Meta Analysis, Review
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Hypersensitivity
Problem Substances : Acetaminophen, Paracetamol
[+]

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men, and the impact is larger on younger individuals.Mar 01, 2010

Pubmed Data : Am J Med. 2010 Mar;123(3):231-7. PMID: 20193831
Article Published Date : Mar 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Drug-Induced Toxicity , Hearing Loss
Problem Substances : Aspirin , Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Tylenol
[+]

Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive.Jan 01, 2002

Pubmed Data : Cochrane Database Syst Rev. 2002(2):CD003676. PMID: 12076499
Article Published Date : Jan 01, 2002
Study Type : Meta Analysis
Additional Links
Diseases : Fever
Problem Substances : Paracetamol, Tylenol
[+]

Paracetamol metabolism by endothelial cells - Potential mechanism underlying intravenous paracetamol-induced hypotension.Dec 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res. 2025 Jan ;211:107540. Epub 2024 Dec 7. PMID: 39653302
Article Published Date : Dec 31, 2024
Study Type : Human In Vitro, Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Hypertension
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen and diphenhydramine premedication for for allergic and febrile nonhemolytic transfusion reactions may be ineffective and unsafe. Jan 01, 2007

Pubmed Data : Transfus Med Rev. 2007 Jan;21(1):1-12. PMID: 17174216
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Blood Transfusion
Problem Substances : Diphenhydramine, Tylenol
[+]

Acetaminophen elevates unbound bilirubin levels by the glucose oxidase-peroxidase method.Aug 31, 2021

Pubmed Data : Pediatr Int. 2021 Sep ;63(9):1069-1074. Epub 2021 Jul 30. PMID: 33464662
Article Published Date : Aug 31, 2021
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Gastrointestinal Diseases
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen exposure during pregnancy was associated with childhood asthmatic symptoms among vulnerable subgroups in this cohort.Sep 25, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2021 Sep 26 ;18(19). Epub 2021 Sep 26. PMID: 34639411
Article Published Date : Sep 25, 2021
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen use after measles-mumps-rubella vaccination is associated with autistic disorder.May 01, 2008

Pubmed Data : Autism. 2008 May;12(3):293-307. PMID: 18445737
Article Published Date : May 01, 2008
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Tylenol
[+]

Acetaminophen use during pregnancy and DNA methylation in the placenta of the extremely low gestational age newborn.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Epigenet. 2019 Apr ;5(2):dvz010. Epub 2019 Aug 6. PMID: 31404209
Article Published Date : Mar 31, 2019
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Infants: Low Birth Weight
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen use during pregnancy is associated with an increased risk for ADHD, ASD, and hyperactivity symptoms.Jul 31, 2018

Pubmed Data : Am J Epidemiol. 2018 Aug 1 ;187(8):1817-1827. PMID: 29688261
Article Published Date : Jul 31, 2018
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen use for fever in children associated with autism spectrum disorder.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Autism Open Access. 2016 Apr ;6(2). Epub 2016 Mar 28. PMID: 27695658
Article Published Date : Mar 31, 2016
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders
Additional Keywords : Endocannabinoid System
Problem Substances : Acetaminophen, Paracetamol
[+]

Acupuncture was found to be a better treatment option than the conventional drug therapy in not only relieving the pain of migraine but in also improving the psychological profile in migraneurs. Dec 31, 2013

Pubmed Data : Indian J Physiol Pharmacol. 2014 Jan-Mar;58(1):69-76. PMID: 25464680
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Diseases : Migraine Disorders
Therapeutic Actions : Electroacupuncture
Additional Keywords : Therapeutic Action Superior to Drug Therapy
Problem Substances : Paracetamol
[+]

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.Sep 01, 2005

Pubmed Data : Pediatr Nephrol. 2005 Sep;20(9):1295-8. Epub 2005 Jun 23. PMID: 15973524
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Children: Drug-Induced Toxicity
Problem Substances : Diclofenac, Dipyrone, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol
Adverse Pharmacological Actions : Nephrotoxic
[+]

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

Pubmed Data : J Infect Dis. 1990 Dec ;162(6):1277-82. PMID: 2172402
Article Published Date : Nov 30, 1990
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Common Cold, Rhinovirus Infection
Additional Keywords : Increased Risk, Viral Shedding
Problem Substances : Acetaminophen, Aspirin , Ibuprofen, Paracetamol
Adverse Pharmacological Actions : Immunosuppressive
[+]

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.Sep 01, 2009

Pubmed Data : Arch Pediatr Adolesc Med. 2009 Sep ;163(9):799-804. PMID: 19736332
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Febrile Seizures, Fever
Problem Substances : Diclofenac, Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol, Tylenol
[+]

Association of acetaminophen use during pregnancy with behavioural problems in childhood.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JAMA Pediatr. 2016 Oct 1 ;170(10):964-970. PMID: 27533796
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit/hyperactivity disorder.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JAMA Pediatr. 2020 Nov 1 ;174(11):1073-1081. PMID: 32986124
Article Published Date : Oct 31, 2020
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity
Problem Substances : Acetaminophen, Paracetamol
[+]

Association of prenatal acetaminophen use and acetaminophen metabolites with DNA methylation of newborns.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Epigenet. 2022 ;8(1):dvac002. Epub 2022 Feb 2. PMID: 35317219
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity
Additional Keywords : DNA Methylation
Problem Substances : Acetaminophen, Paracetamol
[+]

Associations between Acetaminophen Use during Pregnancy and ADHD Symptoms Measured at Ages 7 and 11 Years.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(9):e108210. Epub 2014 Sep 24. PMID: 25251831
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Diseases : Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures
Problem Substances : Paracetamol, Tylenol
[+]

Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities.May 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Allergy Asthma Immunol. 2024 Jun ;132(6):705-712.e5. Epub 2024 Mar 12. PMID: 38484838
Article Published Date : May 31, 2024
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma
Problem Substances : Acetaminophen, Paracetamol
[+]

Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood.Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Paediatr Perinat Epidemiol. 2020 May ;34(3):267-277. Epub 2020 Jan 22. PMID: 31965601
Article Published Date : Apr 30, 2020
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Ibuprofen Toxicity
Problem Substances : Acetaminophen, Ibuprofen, Paracetamol
[+]

Chronic tylenol use is associated wtih an almost two-fold increased risk of blood cancer.May 09, 2011

Pubmed Data : J Clin Oncol. 2011 May 9. Epub 2011 May 9. PMID: 21555699
Article Published Date : May 09, 2011
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Leukemia: Chronic Lymphocytic Leukemia (CLL), Lymphoma
Problem Substances : Tylenol
Adverse Pharmacological Actions : Carcinogenic
[+]

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran Sep 01, 2009

Pubmed Data : Z Gastroenterol. 2009 Sep;47(9):807-13. Epub 2009 Sep 11. PMID: 19750427
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Problem Substances : Tylenol
[+]

Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatric ambulatory surgery.Dec 31, 2009

Pubmed Data : Cir Cir. 2010 ;78(5):400-9. PMID: 21219810
Article Published Date : Dec 31, 2009
Study Type : Human Study
Additional Links
Substances : B-complex
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Acetaminophen, Paracetamol
[+]

Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.May 31, 2000

Pubmed Data : Clin Pharmacol Ther. 2000 Jun ;67(6):591-9. PMID: 10872641
Article Published Date : May 31, 2000
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Alcohol Toxicity , Liver Damage
Additional Keywords : Synergistic Toxicity
Problem Substances : Acetaminophen, Paracetamol
[+]

Exposure to paracetamol in utero was associated with increased risks of motor milestone delay and impaired communication skills in children at 18 months.Nov 30, 2016

Pubmed Data : Int J Epidemiol. 2016 Dec 1 ;45(6):1998-2008. PMID: 27585674
Article Published Date : Nov 30, 2016
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Gestational exposure to acetaminophen was associated with a small increased risk of ADHD.Sep 29, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Am Acad Child Adolesc Psychiatry. 2025 Sep 30. Epub 2025 Sep 30. PMID: 41062061
Article Published Date : Sep 29, 2025
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Neurodevelopmental Disorders, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair.Jun 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Toxicol. 2024 Jul ;98(7):2261-2268. Epub 2024 Apr 14. PMID: 38615315
Article Published Date : Jun 30, 2024
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity
Problem Substances : Acetaminophen, Paracetamol
[+]

Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Epigenetics. 2017 ;9:77. Epub 2017 Aug 2. PMID: 28785368
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures
Additional Keywords : DNA Methylation, Epigenetic Modification
Problem Substances : Acetaminophen, Paracetamol
[+]

Male urinary paracetamol and semen quality.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Andrology. 2017 Nov ;5(6):1082-1088. Epub 2017 Aug 29. PMID: 28853221
Article Published Date : Oct 31, 2017
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Sperm Quality: Low
Problem Substances : Acetaminophen, Paracetamol
[+]

Maternal acetaminophen biomarkers were specifically associated with increased risk of ADHD diagnosis in offspring. Jul 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Sci. 2018 Jul 3 ;8(7). Epub 2018 Jul 3. PMID: 29970852
Article Published Date : Jul 02, 2018
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Hyperactivity Disorder, Prenatal Chemical Exposures
Additional Keywords : Increased Risk
Problem Substances : Acetaminophen, Paracetamol
[+]

Maternal acetaminophen use and cognitive development at 4 years.Feb 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pediatr Res. 2023 Mar ;93(4):959-963. Epub 2022 Jul 7. PMID: 35794252
Article Published Date : Feb 28, 2023
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Maternal acetaminophen use during pregnancy is associated with a higher risk for hyperkinetic disorders and ADHD-like behaviors in children.Mar 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JAMA Pediatr. 2014 Apr ;168(4):313-20. PMID: 24566677
Article Published Date : Mar 31, 2014
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity
Problem Substances : Acetaminophen, Paracetamol
[+]

Maternal acetaminophen use during pregnancy was associated with lower performance IQ in 5-year olds.Oct 31, 2016

Pubmed Data : Epidemiology. 2016 Nov ;27(6):912-8. PMID: 27479646
Article Published Date : Oct 31, 2016
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Maternal exposure to paracetamol is associated with disadvantages to the offspring in scholastic abilities such as mathematics and reading at secondary school ages.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2023 ;14:1116683. Epub 2023 Dec 12. PMID: 38149049
Article Published Date : Dec 31, 2022
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Maternal paracetamol use during pregnancy could be associated with poorer attention and executive function in 5-year-olds.Nov 30, 2016

Pubmed Data : Int J Epidemiol. 2016 Dec 1 ;45(6):2009-2017. PMID: 28031314
Article Published Date : Nov 30, 2016
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Maternal paracetamol use in pregnancy is associated with an enhanced risk of asthma and wheezing in their children.Feb 23, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med. 2023 Feb 24 ;12(5). Epub 2023 Feb 24. PMID: 36902618
Article Published Date : Feb 23, 2023
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures, Wheezing: Infants
Additional Keywords : Increased Risk
Problem Substances : Acetaminophen, Paracetamol
[+]

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2022 ;17(9):e0272593. Epub 2022 Sep 28. PMID: 36170224
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Over the counter cold medications manufactured for children can result in toxicity that can lead to death when given to infants.Oct 01, 2005

Pubmed Data : J Anal Toxicol. 2005 Oct;29(7):738-43. PMID: 16419411
Article Published Date : Oct 01, 2005
Study Type : Human Study
Additional Links
Diseases : Cold and Flu: Infants & Children , Infant Mortality
Problem Substances : Brompheniramine, Carbinoxamine, Chlorpheniramine, Cold Medications, Dextromethorphan, Diphenhydramine, Ephedrine, Ethanol, Levorphanol, Metoclopramide, Pseudoephedrine, Tylenol
[+]

Paracetamol use during pregnancy was associated with an increased risk of asthma and wheezing in childhood.May 31, 2008

Pubmed Data : Int J Epidemiol. 2008 Jun ;37(3):583-90. Epub 2008 Apr 9. PMID: 18400839
Article Published Date : May 31, 2008
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures, Wheezing: Infants
Problem Substances : Acetaminophen, Paracetamol
[+]

Paracetamol was associated with increased mortality, especially cardiovascular.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Behav. 2015 Aug ;5(8):e00338. Epub 2015 May 29. PMID: 26357585
Article Published Date : Jul 31, 2015
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Cardiac Mortality , Inflammation
Additional Keywords : Increased Risk, Mortality, Synergistic Toxicity
Problem Substances : Acetaminophen, Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol
[+]

Patients with RA appear to have less capacity for excreting paracetamol as non-toxic conjugates and may be more susceptible to paracetamol toxicity.Apr 30, 1991

Pubmed Data : Xenobiotica. 1991 May ;21(5):689-93. PMID: 1949902
Article Published Date : Apr 30, 1991
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Rheumatoid Arthritis
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Epidemiol. 2016 12 1 ;45(6):1987-1996. PMID: 27353198
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders, Prenatal Chemical Exposures
Additional Keywords : Risk Factors
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal acetaminophen was associated with adverse birth outcomes.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pediatr. 2022 ;10:828089. Epub 2022 Apr 5. PMID: 35450103
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal and early-life antibiotic exposure and the risk of atopic dermatitis in children.Apr 30, 2023

Pubmed Data : Pediatr Allergy Immunol. 2023 May ;34(5):e13959. PMID: 37232285
Article Published Date : Apr 30, 2023
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Antibiotic Toxicity , Atopic Dermatitis, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Antibiotics, Paracetamol
[+]

Prenatal and infant paracetamol exposure and development of asthma.Mar 31, 2016

Pubmed Data : Int J Epidemiol. 2016 Apr ;45(2):512-22. Epub 2016 Feb 9. PMID: 26861478
Article Published Date : Mar 31, 2016
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal exposure to acetaminophen and children's language development at 30 months.May 31, 2018

Pubmed Data : Eur Psychiatry. 2018 Jun ;51:98-103. Epub 2018 Jan 10. PMID: 29331486
Article Published Date : May 31, 2018
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal exposure to acetaminophen increases the risk of atopic dermatitis in children.Jun 30, 2021

Pubmed Data : Pediatr Allergy Immunol. 2021 Jul ;32(5):1080-1088. Epub 2021 Mar 8. PMID: 33544946
Article Published Date : Jun 30, 2021
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Atopic Dermatitis, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal paracetamol exposure and child neurodevelopment.Nov 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Epidemiol. 2013 Dec ;42(6):1702-13. Epub 2013 Oct 24. PMID: 24163279
Article Published Date : Nov 30, 2013
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Neurodevelopmental Disorders, Prenatal Chemical Exposures
Additional Keywords : Risk Factors
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood.Dec 31, 2004

Pubmed Data : Clin Exp Allergy. 2005 Jan ;35(1):18-25. PMID: 15649261
Article Published Date : Dec 31, 2004
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal paracetamol exposure and risk of wheeze at preschool age.Nov 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Paediatr. 2011 Dec ;100(12):1567-71. Epub 2011 Jul 27. PMID: 21767300
Article Published Date : Nov 30, 2011
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Wheezing: Infants
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Hum Reprod. 2016 Nov ;31(11):2642-2650. Epub 2016 Sep 8. PMID: 27609981
Article Published Date : Oct 31, 2016
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Male Reproductive Development Abnormalities, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study.Mar 31, 2018

Pubmed Data : J Epidemiol Community Health. 2018 Apr ;72(4):349-355. Epub 2018 Jan 25. PMID: 29371328
Article Published Date : Mar 31, 2018
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

The relationship of prenatal acetaminophen exposure and attention-related behavior in early childhood.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurotoxicol Teratol. 2024 ;101:107319. Epub 2024 Jan 8. PMID: 38199313
Article Published Date : Dec 31, 2023
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

This study suggests that use of acetaminophen in middle to late but not early pregnancy may be related to respiratory symptoms in the first year of life.Aug 31, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Allergy Asthma Immunol. 2008 Sep ;101(3):271-8. PMID: 18814450
Article Published Date : Aug 31, 2008
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

This suggests that acetaminophen may not be as safe in pregnancy as is widely believed.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Psychiatry. 2016 Mar ;77(3):e312-4. PMID: 27046315
Article Published Date : Feb 29, 2016
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity
Problem Substances : Acetaminophen, Paracetamol
[+]

Tylenol may have lethal side effects in children.Jan 01, 2007

Pubmed Data : Cas Lek Cesk. 2007;146(4):401-5; discussion 405-6. PMID: 17491251
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Problem Substances : Tylenol
[+]

Tylenol use has been linked to unexplained dyspepsia.Jun 01, 1988

Pubmed Data : Dig Dis Sci. 1988 Jun;33(6):641-8. PMID: 3371135
Article Published Date : Jun 01, 1988
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Dyspepsia
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Tylenol
[+]

The results of this in vitro study suggested that high doses of acetaminophen may cause serious damage towards human mesenchymal stem cells.Jun 18, 2015

Pubmed Data : Int J Mol Med. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26096646
Article Published Date : Jun 18, 2015
Study Type : Human In Vitro
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity
Additional Keywords : Mesenchymal Stem Cells
Problem Substances : Acetaminophen, Paracetamol
Adverse Pharmacological Actions : Cytotoxic
[+]

This study highlights the potential for acetaminophen to interfere with hormone regulation during pregnancy.Jan 05, 2021

Pubmed Data : Toxicol Sci. 2021 Jan 6 ;179(1):44-52. PMID: 33098425
Article Published Date : Jan 05, 2021
Study Type : Human In Vitro
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Endocrine Disruptors, Paracetamol
Adverse Pharmacological Actions : Neurotoxic
[+]

Farrerol ameliorates acetaminophen-induced hepatotoxicity.Dec 31, 2018

Pubmed Data : Int J Biol Sci. 2019 ;15(4):788-799. Epub 2019 Jan 29. PMID: 30906210
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Ferulic acid ameliorates acetaminophen-induced acute liver injury.May 04, 2022

Pubmed Data : IUBMB Life. 2022 May 5. Epub 2022 May 5. PMID: 35514074
Article Published Date : May 04, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ferulic acid
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.Nov 26, 2019

Pubmed Data : Cureus. 2019 Nov 27 ;11(11):e6251. Epub 2019 Nov 27. PMID: 31890447
Article Published Date : Nov 26, 2019
Study Type : Human: Case Report
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Salvianolic acid A protects against acetaminophen-induced hepatotoxicity.Apr 02, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2023 Apr 3 ;12(4). Epub 2023 Apr 3. PMID: 37107244
Article Published Date : Apr 02, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, MicroRNA modulator
Additional Keywords : MicroRNA-485
Problem Substances : Acetaminophen, Paracetamol
[+]

This case highlights the significant morbidity that can occur with even unintentional APAP toxicity and the need to educate patients, especially pregnant patients, of the risk of excessive APAP use.Mar 13, 2012

Pubmed Data : . PMID: 22415886
 
Article Published Date : Mar 13, 2012
Study Type : Human: Case Report
Additional Links
Diseases : Liver Failure: Drug Induced
Problem Substances : Tylenol
[+]

Co-administration of N-Acetylcysteine and Acetaminophen efficiently blocks Acetaminophen toxicity.Jul 31, 2015

Pubmed Data : Drug Dev Res. 2015 Aug ;76(5):251-8. Epub 2015 Aug 7. PMID: 26250417
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacognosy Res. 2013 Oct ;5(4):271-6. PMID: 24174821
Article Published Date : Sep 30, 2013
Study Type : Animal Study
Additional Links
Substances : Fig
Diseases : Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Isoniazid, Paracetamol
[+]

Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice Jun 11, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Prev Med. 2017 Jun 12 ;22(1):54. Epub 2017 Jun 12. PMID: 29165178
Article Published Date : Jun 11, 2017
Study Type : Animal Study
Additional Links
Substances : Bamboo
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

Pubmed Data : J Ayub Med Coll Abbottabad. 2020 Jan- Mar;32(1):28-32. PMID: 32468750
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

A combination of resveratrol and quercetin suppressed glomerular damage and apoptosis induced by acetaminophen in the kidney.Feb 02, 2020

Pubmed Data : Drug Chem Toxicol. 2020 Feb 3:1-7. Epub 2020 Feb 3. PMID: 32013615
Article Published Date : Feb 02, 2020
Study Type : Animal Study
Additional Links
Substances : Quercetin, Resveratrol
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

A combination strategy of thymoquinone and curcumin might be considered as a potential antidote in combating liver injury induced by acetaminophen.Mar 04, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Folia Morphol (Warsz). 2019 Mar 5. Epub 2019 Mar 5. PMID: 30835338
Article Published Date : Mar 04, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin, Thymoquinone
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

A crude aqueous leafy extract of M. indica possesses hepatoprotective effects.Jun 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Future Sci OA. 2022 Jul ;8(6):FSO801. Epub 2022 Jun 17. PMID: 35909999
Article Published Date : Jun 30, 2022
Study Type : Animal Study
Additional Links
Substances : Mango
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

A hepatoprotection study of Radix Bupleuri on acetaminophen-induced liver injury based on CYP450 inhibition.Jun 30, 2019

Pubmed Data : Chin J Nat Med. 2019 Jul ;17(7):517-524. PMID: 31514983
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Bupleurum
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

A methanolic extract of pomegranate peel ameliorated the hepatic damage caused by acetaminophen.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pak Med Assoc. 2016 Jul ;66(7):859-63. PMID: 27427136
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate Peel
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

A single early-life acetaminophen exposure causes persistent abnormalities in the murine lung.Jul 31, 2025

Pubmed Data : Am J Respir Cell Mol Biol. 2025 Aug ;73(2):232-250. PMID: 39836061
Article Published Date : Jul 31, 2025
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Lung Damage
Problem Substances : Acetaminophen, Paracetamol
[+]

A. catechu seed extract is a promising agent for protecting liver from acetaminophen induced hepatotoxicity.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2018 Dec ;108:838-844. Epub 2018 Sep 24. PMID: 30372895
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Acacia catechu
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

Pubmed Data : Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435
Article Published Date : Dec 31, 1999
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen (Paracetamol) metabolites induce vasodilation and hypotension.Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arterioscler Thromb Vasc Biol. 2020 May ;40(5):1207-1219. Epub 2020 Mar 19. PMID: 32188278
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Hypertension
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen (Tylenol) includes the toxicity associated with chronic exposure to depleted uranium. Jan 05, 2007

Pubmed Data : Toxicology. 2007 Jan 5;229(1-2):62-72. Epub 2006 Oct 17. PMID: 17126469
Article Published Date : Jan 05, 2007
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Uranium Poisoning
Additional Keywords : Toxic Substance Synergy
Problem Substances : Tylenol, Uranium
Adverse Pharmacological Actions : Hepatotoxic, Nephrotoxic
[+]

Acetaminophen affects empathy-like behavior in rats.Nov 30, 2018

Pubmed Data : Pharmacol Biochem Behav. 2018 Dec ;175:146-151. Epub 2018 Oct 22. PMID: 30359628
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity
Additional Keywords : Conventional Medicine Erodes Empathy
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.Dec 30, 2015

Pubmed Data : Toxicol Sci. 2015 Dec 31. Epub 2015 Dec 31. PMID: 26721299
Article Published Date : Dec 30, 2015
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Mitochondrial Dysfunction
Problem Substances : Acetaminophen, Paracetamol
[+]

acetaminophen in a subtoxic dose for a long period could result in mild toxic effects on the liver but more serious lesions in the kidney and brain.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Vet J. 2024 Jan ;14(1):316-323. Epub 2024 Jan 31. PMID: 38633179
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen interferes with the first trimester human fetal ovary development.May 16, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Endocrinol Metab. 2022 May 17 ;107(6):1647-1661. PMID: 35147701
Article Published Date : May 16, 2022
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen toxicity is substantially reduced by beta-carotene in mice.Dec 31, 1994

Pubmed Data : Int J Vitam Nutr Res. 1995 ;65(3):175-80. PMID: 8829996
Article Published Date : Dec 31, 1994
Study Type : Animal Study
Additional Links
Substances : beta-Carotene, Carotenoids
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen toxicity to cultured rat embryos.Dec 31, 1989

Pubmed Data : Teratog Carcinog Mutagen. 1990 ;10(5):361-71. PMID: 1981948
Article Published Date : Dec 31, 1989
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity
Problem Substances : Acetaminophen, Paracetamol
Adverse Pharmacological Actions : Teratogenic
[+]

Acetaminophen-induced alterations in blood glucose and blood insulin levels in mice.Feb 29, 1984

Pubmed Data : Res Commun Chem Pathol Pharmacol. 1984 Mar ;43(3):381-91. PMID: 6371954
Article Published Date : Feb 29, 1984
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity
Problem Substances : Acetaminophen, Paracetamol
[+]

Acetaminophen-induced hepatotoxicity predominantly via inhibiting Nrf2 antioxidative pathway.Feb 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicol Environ Saf. 2023 Mar 1 ;252:114590. Epub 2023 Feb 2. PMID: 36738614
Article Published Date : Feb 28, 2023
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation, Oxidative Stress
Problem Substances : Acetaminophen, Paracetamol
[+]

Alleviative effects from boswellic acid on acetaminophen-induced hepatic injury.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicine (Taipei). 2016 Jun ;6(2):9. Epub 2016 May 9. PMID: 27161000
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Boswellic Acid
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Alterations in synaptic plasticity and oxidative stress following long-term paracetamol treatment in rat brain.Jan 31, 2020

Pubmed Data : Neurotox Res. 2020 Feb ;37(2):455-468. Epub 2019 Jul 30. PMID: 31364032
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Problem Substances : Acetaminophen, Paracetamol
Adverse Pharmacological Actions : Neurotoxic
[+]

Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity.Dec 31, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2021 Jan ;28(2):1762-1774. Epub 2020 Aug 27. PMID: 32856245
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Corn Silk
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Renoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

An aqueous extract of white clover was protective against the hepatotoxicity induced by acetaminophen.Aug 31, 2019

Pubmed Data : J Food Biochem. 2019 Sep ;43(9):e12963. Epub 2019 Jul 2. PMID: 31489655
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : White Clover
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

An extract from Mulberry leaf decelerates acetaminophen induced hepatic inflammation.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Drug Anal. 2017 Oct ;25(4):862-871. Epub 2016 Nov 5. PMID: 28987363
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Mulberry
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
Problem Substances : Acetaminophen, Paracetamol
[+]

An isoflavonoid from seeds of Lepidium sativum L. has a protective effect on hepatotoxicity induced by paracetamol.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2014 ;19(10):15440-51. Epub 2014 Sep 26. PMID: 25264831
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Garden Cress (Lepidium sativum)
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen induced liver injury.Apr 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Pharmacol. 2019 Apr 3. Epub 2019 Apr 3. PMID: 30944208
Article Published Date : Apr 02, 2019
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Problem Substances : Acetaminophen, Paracetamol
[+]

Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injuryApr 30, 2018

Pubmed Data : Int J Biol Macromol. 2018 May ;111:1133-1139. Epub 2018 Feb 19. PMID: 29415408
Article Published Date : Apr 30, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation
Problem Substances : Acetaminophen, Paracetamol
[+]

Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro.Apr 30, 2019

Pubmed Data : J Cell Biochem. 2019 May ;120(5):7482-7488. Epub 2018 Oct 30. PMID: 30378160
Article Published Date : Apr 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Antioxidative and anti-Inflammatory protective effects of fucoxanthin against paracetamol-induced hepatotoxicity.Nov 13, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2023 Nov 14 ;21(11). Epub 2023 Nov 14. PMID: 37999416
Article Published Date : Nov 13, 2023
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats.Feb 10, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 Feb 11:e22472. Epub 2020 Feb 11. PMID: 32048452
Article Published Date : Feb 10, 2020
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation
Problem Substances : Acetaminophen, Paracetamol
[+]

Apigenin attenuates acetaminophen-induced hepatotoxicity. Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:549057. Epub 2020 Nov 20. PMID: 33658919
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:514. Epub 2020 Apr 24. PMID: 32425778
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Hepatoprotective, SIRT1 Activator
Problem Substances : Acetaminophen, Paracetamol
[+]

Apigenin significantly increases the enzyme antioxidant defence mechanisms in paracetamol-induced hepatotoxicity.Mar 01, 2017

Pubmed Data : Eur J Drug Metab Pharmacokinet. 2017 Mar 2. Epub 2017 Mar 2. PMID: 28255865
Article Published Date : Mar 01, 2017
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.Jul 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Sci. 2011 Aug ;122(2):598-605. Epub 2011 May 13. PMID: 21572097
Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Problem Substances : Acetaminophen, Paracetamol
[+]

Aqueous extracts of C. papaya may be useful in preventing carbon tetrachloride and acetaminophen induced liver toxicities.Dec 31, 2015

Pubmed Data : J Intercult Ethnopharmacol. 2016 Jan-Feb;5(1):27-35. Epub 2016 Jan 27. PMID: 27069723
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Papaya
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Aqueous extracts of Rosa damascene may prevent hepatic damage from acetaminophen induced toxicity in rats.Dec 31, 2011

Pubmed Data : J Environ Pathol Toxicol Oncol. 2012 ;31(3):193-201. PMID: 23339694
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Rose
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Arctium lappa can prevent most of the hepatic tissue damage caused by acetaminophen overdose in rats.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Ther Res Clin Exp. 2015 Dec ;77:73-8. Epub 2015 May 27. PMID: 26543508
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Burdock
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice.Jun 06, 2016

Pubmed Data : Arch Biochem Biophys. 2016 Jun 7. Epub 2016 Jun 7. PMID: 27288086
Article Published Date : Jun 06, 2016
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid-childhood executive function and behaviour.Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Paediatr Perinat Epidemiol. 2020 May ;34(3):287-298. Epub 2019 Oct 21. PMID: 31637744
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Ibuprofen Toxicity, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Ibuprofen, Paracetamol
[+]

Astaxanthin provided protection for the liver against acetaminophen hepatotoxicity.Jan 29, 2017

Pubmed Data : Int Immunopharmacol. 2017 Jan 30 ;45:26-33. Epub 2017 Jan 30. PMID: 28152447
Article Published Date : Jan 29, 2017
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Astragaloside IV attenuates acetaminophen-induced liver injuries in mice.Aug 13, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Aug 14 ;23(8). Epub 2018 Aug 14. PMID: 30110942
Article Published Date : Aug 13, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

B. trimera a potential candidate drug capable of protecting the liver against damage caused by Acetaminophen overdose.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2014 ;2014:196598. Epub 2014 Nov 12. PMID: 25435714
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Baccharis trimera
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Baccharis trimera improves the antioxidant defense system and inhibits iNOS and NADPH oxidase expression in a rat model of inflammation.Dec 31, 2012

Pubmed Data : Curr Pharm Biotechnol. 2013 ;14(11):975-84. PMID: 24372242
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Baccharis trimera
Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation
Pharmacological Actions : Antioxidants
Additional Keywords : Gene Expression Regulation, Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Basil extract may act as a natural antioxidant to treat acetaminophen -induced acute hepato-renal toxicity when used as a post-treatment.Oct 11, 2018

Pubmed Data : J Complement Integr Med. 2018 Oct 12. Epub 2018 Oct 12. PMID: 30312166
Article Published Date : Oct 11, 2018
Study Type : Animal Study
Additional Links
Substances : Basil
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Berberine exhibits notable preventive effects on acetaminophen induced hepatotoxicity.Jun 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Berberine protects against the hepatic damage induced by ParacetamolFeb 01, 2000

Pubmed Data : Fitoterapia. 2000 Feb ;71(1):25-33. PMID: 11449466
Article Published Date : Feb 01, 2000
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
Problem Substances : Paracetamol
[+]

Beta-glucan and vitamin C co-treatment may be a promising therapeutic option for the treatment of acute acetaminophen hematotoxicity.Mar 17, 2019

Pubmed Data : Drug Chem Toxicol. 2019 Mar 18:1-8. Epub 2019 Mar 18. PMID: 30880499
Article Published Date : Mar 17, 2019
Study Type : Animal Study
Additional Links
Substances : Beta-glucan, Vitamin C
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Acetaminophen, Paracetamol
[+]

Betacyanins, major components in Opuntia red-purple fruits, protect against acetaminophen-induced acute liver failure.Jan 10, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Res Int. 2020 11 ;137:109461. Epub 2020 Jun 18. PMID: 33233135
Article Published Date : Jan 10, 2020
Study Type : Animal Study
Additional Links
Substances : Prickly Pear Cactus
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Betanin exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by paracetamol and diclofenac over consumption.Nov 25, 2019

Pubmed Data : Biomarkers. 2019 Nov 26:1-24. Epub 2019 Nov 26. PMID: 31766895
Article Published Date : Nov 25, 2019
Study Type : Animal Study
Additional Links
Substances : Betanin
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Diclofenac, Paracetamol
[+]

Betulinic acid can be used as an effective agent in the prevention and treatment of acute liver diseases.Mar 27, 2021

Pubmed Data : Turk J Med Sci. 2021 Mar 28. Epub 2021 Mar 28. PMID: 33773522
Article Published Date : Mar 27, 2021
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Bitter apple fruit possess significant hepatoprotective and antioxidant activity.Apr 30, 2015

Pubmed Data : Pak J Pharm Sci. 2015 May ;28(3):951-7. PMID: 26004728
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Bitter Apple
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Paracetamol
[+]

Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.Sep 30, 2014

Pubmed Data : Int J Pharm. 2014 Oct 1 ;473(1-2):485-92. Epub 2014 Jul 24. PMID: 25066077
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Bixin
Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.Apr 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Apr 21 ;22(4). Epub 2017 Apr 21. PMID: 28430162
Article Published Date : Apr 20, 2017
Study Type : Animal Study
Additional Links
Substances : Ginsenosides, Panax Ginseng
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy
Problem Substances : Acetaminophen, Paracetamol
[+]

Both the lower and higher dose exposures resulted in measurable changes in lung morphometrics, with the lower dose exposure causing alveolar wall thinning.Oct 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1 ;321(5):L941-L953. Epub 2021 Sep 29. PMID: 34585971
Article Published Date : Oct 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Lung Damage
Problem Substances : Acetaminophen, Paracetamol
[+]

Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis.Sep 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Toxicol Pathol. 2018 Oct ;31(4):275-282. Epub 2018 Jul 1. PMID: 30393431
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Propolis: Brazillian
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Carnosic acid protected against acetaminophen induced liver injury and enhanced antioxidant defence system.Dec 31, 2015

Pubmed Data : Korean J Physiol Pharmacol. 2016 Jan ;20(1):15-23. Epub 2015 Dec 31. PMID: 26807019
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Chlorogenic acid promotes liver regeneration and repair after acetaminophen-induced liver injury.Sep 28, 2025

Pubmed Data : Food Funct. 2025 Sep 29 ;16(19):7590-7606. Epub 2025 Sep 29. PMID: 40969002
Article Published Date : Sep 28, 2025
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Additional Keywords : Liver Regeneration
Problem Substances : Acetaminophen, Paracetamol
[+]

Chrysin mitigated side effects of acute Paracetamol toxicity in male reproductive system proportionally in a dose-dependent manner.Feb 23, 2016

Pubmed Data : Andrologia. 2016 Feb 24. Epub 2016 Feb 24. PMID: 26914515
Article Published Date : Feb 23, 2016
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Cytoprotective
Additional Keywords : Dose Response
Problem Substances : Acetaminophen, Paracetamol
[+]

Chrysin possesses restorative effect against paracetamol induced hepatotoxicity.Oct 31, 2017

Pubmed Data : J Biochem Mol Toxicol. 2017 Nov ;31(11). Epub 2017 Jul 6. PMID: 28682524
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective
Additional Keywords : Acetaminophen (Tylenol) Toxicity, Anti-Apoptotic, Antioxidants, Chrysin, Hepatoprotective, Lipid Peroxidation
Problem Substances : Acetaminophen, Paracetamol
[+]

Chrysin prevents the necrosis and injury of acute acetaminophen-induced hepatotoxicity.Nov 17, 2019

Pubmed Data : Chem Res Toxicol. 2019 Nov 18 ;32(11):2329-2337. Epub 2019 Nov 1. PMID: 31625388
Article Published Date : Nov 17, 2019
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Cinnamon oil against acetaminophen-induced acute liver toxicity by attenuating inflammation, oxidative stress and apoptosis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Rep. 2020 ;7:1296-1304. Epub 2020 Sep 17. PMID: 33024703
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Cinnamon
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Cinnamon oil could be an alternative nutraceutical substitute in APAP overdose poisoning.Feb 28, 2022

Pubmed Data : Drug Chem Toxicol. 2022 Mar ;45(2):633-640. Epub 2020 Apr 5. PMID: 32249599
Article Published Date : Feb 28, 2022
Study Type : Animal Study
Additional Links
Substances : Cinnamon
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Acetaminophen, Paracetamol
[+]

Co-administration of fresh grape fruit juice and bergamottin prevented paracetamol induced hepatotoxicity.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Rep. 2015 ;2:677-684. Epub 2015 May 8. PMID: 28962403
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Bergamot
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.Jun 24, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Jun 25 ;18(1):195. Epub 2018 Jun 25. PMID: 29940935
Article Published Date : Jun 24, 2018
Study Type : Animal Study
Additional Links
Substances : Coconut Water
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Inflammation
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Commonly taken analgesics could decrease germ cell number and ovarian size in F1 offspring in rats.Jan 26, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Jan 27 ;6:19789. Epub 2016 Jan 27. PMID: 26813099
Article Published Date : Jan 26, 2016
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Infertility: Female, Prenatal Chemical Exposures
Additional Keywords : Acetaminophen (Tylenol) Toxicity, Infertility: Female, Prenatal Chemical Exposures, Transgenerational Epigenetic Modification
Problem Substances : Acetaminophen, Analgesic: Non-opioid, Indomethacin, Paracetamol
[+]

Comparative hepatoprotective effect of Nigella sativa pre- and post-treatment.Dec 31, 2018

Pubmed Data : Pak J Pharm Sci. 2019 Jan ;32(1):205-212. PMID: 30772810
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective, Prophylactic Agents
Problem Substances : Acetaminophen, Paracetamol
[+]

Comparison of active ingredients and protective effects of Dendrobium huoshanense of different growth years on acute liver injury.Dec 31, 2020

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2021 Jan ;46(2):298-305. PMID: 33645115
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Orchid
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Comparison of ameliorative effects of Taraxacum syriacum and N-acetylcysteine against acetaminophen-induced oxidative stress in the liver and kidney.Sep 23, 2020

Pubmed Data : J Biochem. 2020 Sep 24. Epub 2020 Sep 24. PMID: 32970799
Article Published Date : Sep 23, 2020
Study Type : Animal Study
Additional Links
Substances : Dandelion , NAC (N-acetyl-L-cysteine)
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

CoQ10 promotes resolution of necrosis and liver regeneration after acetaminophen-induced liver injury.Dec 27, 2021

Pubmed Data : Toxicol Sci. 2021 Dec 28 ;185(1):19-27. PMID: 34668565
Article Published Date : Dec 27, 2021
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Additional Keywords : Liver Regeneration
Problem Substances : Acetaminophen, Paracetamol
[+]

Corylin exhibited favorable safety profiles and significant hepatoprotective effects in mice with APAP-induced liver injury.Dec 14, 2025

Pubmed Data : Bioorg Med Chem. 2025 Dec 15 ;131:118433. Epub 2025 Oct 6. PMID: 41066958
Article Published Date : Dec 14, 2025
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Curcumin prevents paracetamol-induced liver mitochondrial alterations.Jan 14, 2016

Pubmed Data : J Pharm Pharmacol. 2016 Jan 15. Epub 2016 Jan 15. PMID: 26773315
Article Published Date : Jan 14, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Dandelion extracts pretreatment protects against acetaminophen-induced hepatic injury.Nov 23, 2021

Pubmed Data : Chin J Integr Med. 2021 Nov 24. Epub 2021 Nov 24. PMID: 34816363
Article Published Date : Nov 23, 2021
Study Type : Animal Study
Additional Links
Substances : Dandelion
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity.Jan 31, 2020

Pubmed Data : Chin J Nat Med. 2020 Feb ;18(2):103-113. PMID: 32172946
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Dandelion , Polyphenols
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata.Aug 31, 2015

Pubmed Data : Environ Toxicol Pharmacol. 2015 Sep ;40(2):369-74. Epub 2015 Jul 4. PMID: 26233562
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury.Dec 31, 2018

Pubmed Data : Toxicol Res (Camb). 2019 Jan 1 ;8(1):67-76. Epub 2018 Oct 25. PMID: 30713662
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Diallyl sulfide
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Dual anti-inflammatory effects of curcumin and berberine on acetaminophen-induced liver injury.Nov 18, 2024

Pubmed Data : Biochem Biophys Res Commun. 2024 Nov 19 ;734:150772. Epub 2024 Sep 30. PMID: 39362031
Article Published Date : Nov 18, 2024
Study Type : Animal Study
Additional Links
Substances : Berberine, Curcumin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Early exposure to paracetamol reduces level of testicular testosterone and changes gonadal expression of genes relevant for steroidogenesis in rats offspring.Jun 30, 2022

Pubmed Data : Drug Chem Toxicol. 2022 Jul ;45(4):1862-1869. Epub 2021 Mar 3. PMID: 33657953
Article Published Date : Jun 30, 2022
Study Type : Animal Study
Additional Links
Substances : Testosterone
Diseases : Acetaminophen (Tylenol) Toxicity , Low Testosterone, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Early paracetamol exposure decreases brain-derived neurotrophic factor (BDNF) in striatum and affects social behaviour and exploration in rats.Apr 30, 2018

Pubmed Data : Pharmacol Biochem Behav. 2018 May ;168:25-32. Epub 2018 Mar 13. PMID: 29545027
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity
Problem Substances : Acetaminophen, Paracetamol
[+]

Early paracetamol exposure produces major changes in serotonergic and dopaminergic neurotransmission in the prefrontal cortex and striatum.Apr 13, 2017

Pubmed Data : Behav Brain Res. 2017 Apr 14 ;323:162-171. Epub 2017 Feb 3. PMID: 28163096
Article Published Date : Apr 13, 2017
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Echinacoside alleviates acetaminophen-induced liver injury.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Appl Biomed. 2021 05 ;19(2):105-112. Epub 2021 Apr 26. PMID: 34907710
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Echinacea
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol.Mar 31, 2019

Pubmed Data : Chem Biol Interact. 2019 Apr 1 ;302:123-134. Epub 2019 Feb 19. PMID: 30794797
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Milk Thistle
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Effect of polysaccharide peptide (PSP) on glutathione and protection against paracetamol-induced hepatotoxicity.Nov 30, 1994

Pubmed Data : Methods Find Exp Clin Pharmacol. 1994 Dec ;16(10):723-9. PMID: 7723471
Article Published Date : Nov 30, 1994
Study Type : Animal Study
Additional Links
Substances : Turkey Tail Mushroom
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Additional Keywords : Polysaccharides
Problem Substances : Acetaminophen, Paracetamol
[+]

Effect of prenatal and early life paracetamol exposure on the level of neurotransmitters in rats--Focus on the spinal cord.Nov 30, 2015

Pubmed Data : Int J Dev Neurosci. 2015 Dec ;47(Pt B):133-9. Epub 2015 Sep 25. PMID: 26390956
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Effect of sesame oil against acetaminophen-induced acute oxidative hepatic damage in rats.Jul 31, 2008

Pubmed Data : Shock. 2008 Aug ;30(2):217-21. PMID: 18091569
Article Published Date : Jul 31, 2008
Study Type : Animal Study
Additional Links
Substances : Sesame Seed Oil
Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion.Jun 30, 1993

Pubmed Data : Xenobiotica. 1993 Jul ;23(7):809-19. PMID: 8237062
Article Published Date : Jun 30, 1993
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Glutathione Deficiency
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Effects of exposure to acetaminophen and ibuprofen on fetal germ cell development.Apr 15, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2018 Apr 16 ;126(4):047006. Epub 2018 Apr 16. PMID: 29665328
Article Published Date : Apr 15, 2018
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Ibuprofen Toxicity
Problem Substances : Acetaminophen, Ibuprofen, Paracetamol
[+]

Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats.Apr 30, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ren Fail. 2010 May ;32(4):493-7. PMID: 20446790
Article Published Date : Apr 30, 2010
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Oxidative Stress
Therapeutic Actions : Ozone Therapy
Pharmacological Actions : Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Effects of sesame oil against after the onset of acetaminophen-induced acute hepatic injury in rats.Dec 31, 2009

Pubmed Data : JPEN J Parenter Enteral Nutr. 2010 ;34(5):567-73. PMID: 20852187
Article Published Date : Dec 31, 2009
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy
Problem Substances : Acetaminophen, Paracetamol
[+]

Elderly mice with history of acetaminophen intoxication display worsened cognitive impairment and persistent elevation of astrocyte and microglia burden.Jun 19, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2024 Jun 20 ;14(1):14205. Epub 2024 Jun 20. PMID: 38902507
Article Published Date : Jun 19, 2024
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Aging, Cognitive Decline/Dysfunction
Problem Substances : Acetaminophen, Paracetamol
[+]

Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway.Aug 17, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Inflammation. 2021 Aug 18. Epub 2021 Aug 18. PMID: 34409550
Article Published Date : Aug 17, 2021
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation-loading fisetin against acetaminophen-induced liver injury.Oct 10, 2021

Pubmed Data : Nanomedicine (Lond). 2021 Oct 11. Epub 2021 Oct 11. PMID: 34632809
Article Published Date : Oct 10, 2021
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Eriodictyol may be used to treat acetaminophen-induced hepatotoxicity.Jan 04, 2017

Pubmed Data : Mol Pharm. 2017 09 5 ;14(9):2937-2951. Epub 2017 Jul 17. PMID: 28654297
Article Published Date : Jan 04, 2017
Study Type : Animal Study
Additional Links
Substances : Eriodictyol
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation
Problem Substances : Acetaminophen, Paracetamol
[+]

Escin protects against acetaminophen-induced liver injury.Dec 31, 2018

Pubmed Data : Am J Transl Res. 2019 ;11(8):5170-5182. Epub 2019 Aug 15. PMID: 31497232
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Horse Chestnut
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Essential oils of green cumin and chamomile partially protect against acute acetaminophen hepatotoxicity in rats.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : An Acad Bras Cienc. 2018 Aug ;90(2 suppl 1):2347-2358. Epub 2018 Jun 25. PMID: 29947676
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Chamomile, Cumin
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Evaluation of Annona muricata for hepatoprotection, hematological assessment and inhibitor of TGFβR1 in liver diseases.Sep 30, 2025

Pubmed Data : Arch Physiol Biochem. 2025 Oct ;131(5):763-780. Epub 2025 May 13. PMID: 40364510
Article Published Date : Sep 30, 2025
Study Type : Animal Study
Additional Links
Substances : Soursop
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Deliv. 2022 Dec ;29(1):3256-3269. PMID: 36321805
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Evaluation of the reparative effect of sinomenine in an acetaminophen-induced liver injury model.Jan 20, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Issues Mol Biol. 2024 Jan 21 ;46(1):923-933. Epub 2024 Jan 21. PMID: 38275673
Article Published Date : Jan 20, 2024
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Even when taken in small doses, paracetamol causes changes in liver metabolism when taken for an extended period of time.Sep 30, 2007

Pubmed Data : Exp Toxicol Pathol. 2007 Oct ;59(2):139-41. Epub 2007 Jun 29. PMID: 17601712
Article Published Date : Sep 30, 2007
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Problem Substances : Acetaminophen, Paracetamol
[+]

Exploration of the protective mechanism of naringin in the acetaminophen-induced hepatic injury by metabolomics.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:7138194. Epub 2022 Sep 16. PMID: 36160708
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Exposure to acetaminophen impairs gametogenesis and fertility in zebrafish.Dec 31, 2022

Pubmed Data : Arch Toxicol. 2023 Jan ;97(1):263-278. Epub 2022 Sep 27. PMID: 36167911
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Infertility
Problem Substances : Acetaminophen, Paracetamol
[+]

Exposure to acetaminophen impairs vasodilation, increases oxidative stress and changes arterial morphology of rats.Apr 23, 2019

Pubmed Data : Arch Toxicol. 2019 Apr 24. Epub 2019 Apr 24. PMID: 31020376
Article Published Date : Apr 23, 2019
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Problem Substances : Acetaminophen, Paracetamol
[+]

Extra virgin olive oil protects the testis and blood from the toxicity of paracetamol.Oct 13, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biology (Basel). 2021 Oct 14 ;10(10). Epub 2021 Oct 14. PMID: 34681141
Article Published Date : Oct 13, 2021
Study Type : Animal Study
Additional Links
Substances : Olive Oil
Diseases : Acetaminophen (Tylenol) Toxicity , Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants
Problem Substances : Acetaminophen, Paracetamol
[+]

Extract of Triticum aestivum sprouts suppresses acetaminophen-induced hepatotoxicity in mice.Oct 19, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Oct 20 ;26(21). Epub 2021 Oct 20. PMID: 34770745
Article Published Date : Oct 19, 2021
Study Type : Animal Study
Additional Links
Substances : Wheat Grass
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Extracts of J. communis leaves was found to be potent antioxidant and hepatoprotective without any cytotoxicity.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2017 Jan-Mar;13(49):108-113. PMID: 28216892
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Juniper
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Fermented ginseng was shown to possess hepatoprotective activity against paracetamol (APAP)-induced liver injury.Mar 31, 2015

Pubmed Data : J Pharm Pharmacol. 2015 Apr ;67(4):565-72. Epub 2014 Dec 10. PMID: 25495794
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Panax Ginseng
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Fisetin attenuates paracetamol-induced hepatotoxicity by regulating CYP2E1 enzyme.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : An Acad Bras Cienc. 2023 ;95(2):e20201408. Epub 2023 Apr 3. PMID: 37018834
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Fisetin prevents acetaminophen-induced liver injury by promoting autophagy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:162. Epub 2020 Feb 28. PMID: 32184730
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(2):e0170900. Epub 2017 Feb 24. PMID: 28234915
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Isoflavones
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Fucoxanthin offers significant hepatoprotection against paracetamol-induced liver injury.Mar 31, 2025

Pubmed Data : Drug Dev Ind Pharm. 2025 Apr ;51(4):332-343. Epub 2025 Feb 28. PMID: 39992072
Article Published Date : Mar 31, 2025
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin , NAC (N-acetyl-L-cysteine)
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Galangin provides significant protection against acetaminophen induced liver and kidney damage.Oct 31, 2015

Pubmed Data : J Med Food. 2015 Nov ;18(11):1187-97. Epub 2015 Jun 4. PMID: 26501381
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny.Oct 19, 2019

Pubmed Data : Neurotoxicol Teratol. 2019 Oct 20 ;77:106838. Epub 2019 Oct 20. PMID: 31644948
Article Published Date : Oct 19, 2019
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
Adverse Pharmacological Actions : Neurotoxic
[+]

Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes.Nov 30, 2006

Pubmed Data : Toxicol Appl Pharmacol. 2006 Dec 1 ;217(2):225-33. Epub 2006 Sep 12. PMID: 17045319
Article Published Date : Nov 30, 2006
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Ginsenoside Rb1 exerts protective effects against acetaminophen-induced hepatotoxicity.Dec 01, 2019

Pubmed Data : Am J Chin Med. 2019 Dec 2:1-17. Epub 2019 Dec 2. PMID: 31786947
Article Published Date : Dec 01, 2019
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:1027731. Epub 2022 Oct 7. PMID: 36278209
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Ginsenoside Rg1 prevents acetaminophen-induced oxidative stress and apoptosis.Jan 03, 2019

Pubmed Data : J Asian Nat Prod Res. 2019 Jan 4:1-16. Epub 2019 Jan 4. PMID: 30608002
Article Published Date : Jan 03, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Ginsenoside Rg1 protects against acetaminophen-induced liver injury.Jul 16, 2018

Pubmed Data : Regul Toxicol Pharmacol. 2018 Jul 17 ;98:58-68. Epub 2018 Jul 17. PMID: 30030101
Article Published Date : Jul 16, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity.Mar 05, 2021

Pubmed Data : J Pharm Pharmacol. 2021 Mar 6 ;73(3):322-331. PMID: 33793882
Article Published Date : Mar 05, 2021
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity.Apr 01, 2018

Pubmed Data : Int Immunopharmacol. 2018 Apr 2 ;59:21-30. Epub 2018 Apr 2. PMID: 29621733
Article Published Date : Apr 01, 2018
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Ginsenoside Rg5 exerts a liver protection effect against acetaminophen-induced acute hepatotoxicity.Oct 24, 2017

Pubmed Data : J Agric Food Chem. 2017 Oct 25 ;65(42):9226-9236. Epub 2017 Oct 16. PMID: 28965396
Article Published Date : Oct 24, 2017
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Malondialdehyde Down-regulation
Problem Substances : Acetaminophen, Paracetamol
[+]

Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2019 Jan ;43(1):10-19. Epub 2017 Jul 25. PMID: 30662289
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Ginsenoside Rk3 shows potential as a novel hepatoprotective agent to prevent drug-induced liver injury.Aug 15, 2021

Pubmed Data : Food Funct. 2021 Aug 16. Epub 2021 Aug 16. PMID: 34397062
Article Published Date : Aug 15, 2021
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Ginsenosides from the leaves of Panax quinquefolius ameliorated acetaminophen-induced hepatotoxicity in mice.May 09, 2017

Pubmed Data : J Agric Food Chem. 2017 May 10 ;65(18):3684-3692. Epub 2017 Apr 25. PMID: 28429935
Article Published Date : May 09, 2017
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Malondialdehyde Down-regulation
Problem Substances : Acetaminophen, Paracetamol
[+]

Glabridin attenuates paracetamol-induced liver injury.Jul 06, 2021

Pubmed Data : Drug Chem Toxicol. 2021 Jul 7:1-9. Epub 2021 Jul 7. PMID: 34233566
Article Published Date : Jul 06, 2021
Study Type : Animal Study
Additional Links
Substances : Licorice
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Glycyrrhizic acid promotes liver regeneration through activating β-catenin in acetaminophen-induced liver injury.Jun 11, 2025

Pubmed Data : J Ethnopharmacol. 2025 Jun 12 ;349:119895. Epub 2025 Apr 28. PMID: 40306499
Article Published Date : Jun 11, 2025
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Gold nanoparticles played a beneficial role in reducing acetaminophen induced toxicity.Jan 29, 2017

Pubmed Data : Exp Toxicol Pathol. 2017 Jan 30. Epub 2017 Jan 30. PMID: 28153389
Article Published Date : Jan 29, 2017
Study Type : Animal Study
Additional Links
Substances : Gold (nanoparticles)
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective, Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Goldenseal has hepatoprotective effects that ameliorate acetaminophen induced acute liver failure in rats.Sep 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacognosy Res. 2011 Oct ;3(4):250-5. PMID: 22224048
Article Published Date : Sep 30, 2011
Study Type : Animal Study
Additional Links
Substances : Goldenseal
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Grape seeds extract provided biochemical and histo-pathological improvement in paracetamol induced renal cortical toxicity. Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bratisl Lek Listy. 2017 ;118(4):233-242. PMID: 28471235
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Guavinoside B from Psidium guajava alleviates acetaminophen-induced liver injury.Sep 22, 2020

Pubmed Data : Food Funct. 2020 Sep 23 ;11(9):8297-8308. PMID: 32909594
Article Published Date : Sep 22, 2020
Study Type : Animal Study
Additional Links
Substances : Guava
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice.Jun 30, 2018

Pubmed Data : J Hepatol. 2018 Jul ;69(1):51-59. Epub 2018 Mar 8. PMID: 29524531
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Additional Keywords : Microbiota
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepato and Nephro protective potentials of lyophilized juice of Citrus reticulata L. fruit against paracetamol induced toxicity in rats.Apr 30, 2024

Pubmed Data : Pak J Pharm Sci. 2024 May ;37(3):553-562. PMID: 39340846
Article Published Date : Apr 30, 2024
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Orange: Mandarin, Polyphenols
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective, Renoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatocyte-specific MET deletion exacerbates acetaminophen-induced hepatotoxicity in mice.Sep 29, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Pathol. 2025 Sep 30. Epub 2025 Sep 30. PMID: 41038273
Article Published Date : Sep 29, 2025
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective actions of ascorbic acid, alpha lipoic acid and silymarin or their combination against acetaminophen-induced hepatotoxicity in rats.May 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicina (Kaunas). 2019 May 21 ;55(5). Epub 2019 May 21. PMID: 31117289
Article Published Date : May 20, 2019
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid, Silibinin, Vitamin C
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidant, Hepatoprotective
Additional Keywords : Natural Substance Synergy
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit.Feb 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Access Maced J Med Sci. 2019 Feb 28 ;7(4):536-542. Epub 2019 Feb 27. PMID: 30894908
Article Published Date : Feb 27, 2019
Study Type : Animal Study
Additional Links
Substances : Passion Flower
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Kidney Damage: Chemically-Induced
Pharmacological Actions : Hepatoprotective, Renoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.Nov 30, 2011

Pubmed Data : Food Chem Toxicol. 2011 Dec ;49(12):3367-73. Epub 2011 Sep 29. PMID: 21983487
Article Published Date : Nov 30, 2011
Study Type : Animal Study
Additional Links
Substances : Andrographis
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective activity of andrographolide possibly through antioxidative defense mechanism.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Rep. 2022 ;9:1013-1022. Epub 2022 Apr 22. PMID: 36518448
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective activity of yellow chinese chive against acetaminophen-induced acute liver injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2020 ;66(4):357-363. PMID: 32863309
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Chives
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective and antioxidant potential of Pycnogenol in acetaminophen-induced hepatotoxicity in rats.Dec 15, 2018

Pubmed Data : Phytother Res. 2018 Dec 16. Epub 2018 Dec 16. PMID: 30556209
Article Published Date : Dec 15, 2018
Study Type : Animal Study
Additional Links
Substances : Pycnogenol (Pine Bark)
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective effect of allicin against acetaminophen-induced liver injury.Feb 09, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 Feb 10:e22470. Epub 2020 Feb 10. PMID: 32040233
Article Published Date : Feb 09, 2020
Study Type : Animal Study
Additional Links
Substances : Allicin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity.Nov 17, 2019

Pubmed Data : J Immunoassay Immunochem. 2019 Nov 18:1-13. Epub 2019 Nov 18. PMID: 31739724
Article Published Date : Nov 17, 2019
Study Type : Animal Study
Additional Links
Substances : Artichoke, Silymarin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury.Mar 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Res. 2021 Apr ;37(2):261-275. Epub 2020 Sep 7. PMID: 33868982
Article Published Date : Mar 31, 2021
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-4 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective effect of dried red jujube fruit extract against acetaminophen-induced acute hepatotoxicity.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2023 Jan ;15(1):e33272. Epub 2023 Jan 2. PMID: 36606101
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective effect of Phellinus linteus mycelia polysaccharide (PL-N1) against acetaminophen-induced liver injury.Nov 19, 2019

Pubmed Data : Int J Biol Macromol. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31758991
Article Published Date : Nov 19, 2019
Study Type : Animal Study
Additional Links
Substances : Phellinus Linteus
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.Jul 14, 2018

Pubmed Data : Int J Biol Macromol. 2018 Jul 15 ;114:137-142. Epub 2018 Mar 20. PMID: 29572139
Article Published Date : Jul 14, 2018
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective
Additional Keywords : Polysaccharides
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective effects of olive leaf extract against carbon tetrachloride-induced oxidative stress.Dec 13, 2024

Pubmed Data : J Mol Histol. 2024 Dec 14 ;56(1):42. Epub 2024 Dec 14. PMID: 39673562
Article Published Date : Dec 13, 2024
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract
Diseases : Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective effects of walnut oil and Caralluma tuberculata against paracetamol in experimentally induced liver toxicity in mice.Oct 23, 2022

Pubmed Data : Acta Biochim Pol. 2022 Oct 24 ;69(4):871-878. PMID: 36279514
Article Published Date : Oct 23, 2022
Study Type : Animal Study
Additional Links
Substances : Walnut
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective effects of zerumbone against paracetamol-induced acute hepatotoxicity.Feb 28, 2018

Pubmed Data : Malays J Med Sci. 2018 Mar ;25(2):64-71. Epub 2018 Apr 27. PMID: 30918456
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Zerumbone
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice.Dec 05, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2011 Dec 6 ;16(12):10134-45. Epub 2011 Dec 6. PMID: 22146374
Article Published Date : Dec 05, 2011
Study Type : Animal Study
Additional Links
Substances : Butterfly Pea, Flavonoids
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective potential of Diospyros melanoxylon (Roxb.) leaf extract.Jan 09, 2026

Pubmed Data : J Ethnopharmacol. 2026 Jan 10 ;354:120489. Epub 2025 Aug 29. PMID: 40886866
Article Published Date : Jan 09, 2026
Study Type : Animal Study
Additional Links
Substances : Persimmon
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatoprotective property of oral silymarin is comparable to N-Acetyl cysteine in acetaminophen poisoning. Sep 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gastroenterology Res. 2012 Oct ;5(5):190-194. Epub 2012 Sep 20. PMID: 27785204
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Silymarin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Hepatotoxicity of acetaminophen in neonatal and young rats. II. Metabolic aspects.Jun 14, 1984

Pubmed Data : Toxicol Appl Pharmacol. 1984 Jun 15 ;74(1):125-33. PMID: 6729817
Article Published Date : Jun 14, 1984
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced
Problem Substances : Acetaminophen, Paracetamol
[+]

Higher prenatal acetaminophen use during pregnancy may be associated with poorer early language development.May 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pediatr Res. 2024 Jun ;95(7):1883-1896. Epub 2023 Dec 11. PMID: 38081897
Article Published Date : May 31, 2024
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Histological changes in kidney structure following a long-term administration of paracetamol (acetaminophen) in pregnant Sprague Dawley rats.Dec 31, 2005

Pubmed Data : Niger J Physiol Sci. 2006 ;21(1-2):77-81. PMID: 17242723
Article Published Date : Dec 31, 2005
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced
Problem Substances : Acetaminophen, Paracetamol
[+]

Honokiol alleviates acetaminophen-induced hepatotoxicity.Jul 31, 2019

Pubmed Data : Life Sci. 2019 Aug 1 ;230:97-103. Epub 2019 May 24. PMID: 31129139
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Honokiol attenuates acetaminophen-induced acute liver injury.Mar 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin Herb Med. 2023 Apr ;15(2):231-239. Epub 2023 Mar 29. PMID: 37265773
Article Published Date : Mar 31, 2023
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Mitochondrial Dysfunction
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.Apr 13, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2015 Apr 14 ;21(14):4195-209. PMID: 25892869
Article Published Date : Apr 13, 2015
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Hyperbaric oxygen treatment and N-acetylcysteine ameliorate acetaminophen-induced liver injury in a rat model. Sep 30, 2013

Pubmed Data : Hum Exp Toxicol. 2013 Oct ;32(10):1107-16. Epub 2013 Aug 7. PMID: 23925941
Article Published Date : Sep 30, 2013
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Hypericum perforatum reduces paracetamol-induced hepatotoxicity and lethality.Jun 30, 2015

Pubmed Data : Phytother Res. 2015 Jul ;29(7):1097-101. Epub 2015 Apr 8. PMID: 25851311
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injury.Feb 15, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Feb 16 ;7:42736. Epub 2017 Feb 16. PMID: 28205631
Article Published Date : Feb 15, 2017
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Problem Substances : Acetaminophen, Paracetamol
[+]

Impaired brainstem auditory evoked potentials after in utero exposure to high dose paracetamol exposure.Nov 30, 2024

Pubmed Data : Hear Res. 2024 Dec ;454:109149. Epub 2024 Nov 12. PMID: 39550993
Article Published Date : Nov 30, 2024
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Commun Biol. 2019 ;2:310. Epub 2019 Aug 13. PMID: 31428698
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Aging, Ibuprofen Toxicity
Problem Substances : Acetaminophen, Paracetamol
[+]

In vivo effects of acetaminophen on rat RBC and role of vitamin E.Mar 31, 1995

Pubmed Data : Indian J Exp Biol. 1995 Apr ;33(4):269-71. PMID: 7558183
Article Published Date : Mar 31, 1995
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Acetaminophen, Paracetamol
[+]

In vivo hepatoprotective potential of extracts obtained from floral spikes of Prunella vulgaris LMar 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ayurveda Integr Med. 2020 Mar 31. Epub 2020 Mar 31. PMID: 32241633
Article Published Date : Mar 30, 2020
Study Type : Animal Study
Additional Links
Substances : Prunella vulgaris
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Induction of chromosome aberrations in vivo in bone-marrow cells of mice by paracetamol.Dec 31, 1994

Pubmed Data : Rom J Morphol Embryol. 1995 ;41(3-4):117-20. PMID: 8772366
Article Published Date : Dec 31, 1994
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , DNA damage
Problem Substances : Acetaminophen, Paracetamol
[+]

Inhibitory activity of black mulberry extract against testicular, liver and kidney toxicity induced by paracetamol.Jan 24, 2020

Pubmed Data : Mol Biol Rep. 2020 Jan 25. Epub 2020 Jan 25. PMID: 31983015
Article Published Date : Jan 24, 2020
Study Type : Animal Study
Additional Links
Substances : Mulberry
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Inhibitory effect of acetaminophen on ocular pigmentation and its relationship with thyroxine in zebrafish embryos.Feb 13, 2024

Pubmed Data : Bull Environ Contam Toxicol. 2024 Feb 14 ;112(2):39. Epub 2024 Feb 14. PMID: 38353786
Article Published Date : Feb 13, 2024
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
Adverse Pharmacological Actions : Teratogenic
[+]

Intergenerational effects on mouse sperm quality after in utero exposure to acetaminophen and ibuprofen.Dec 31, 2018

Pubmed Data : FASEB J. 2019 Jan ;33(1):339-357. Epub 2018 Jul 6. PMID: 29979629
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Male Reproductive Development Abnormalities
Additional Keywords : Transgenerational Epigenetic Modification
Problem Substances : Acetaminophen, Ibuprofen, Paracetamol
[+]

Intrauterine exposure to paracetamol at levels commonly observed in pregnant women may block primordial germ cell proliferation.Feb 29, 2016

Pubmed Data : Toxicol Sci. 2016 Mar ;150(1):178-89. Epub 2016 Jan 5. PMID: 26732887
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Infertility: Female, Prenatal Chemical Exposures
Additional Keywords : Risk Factors
Problem Substances : Acetaminophen, Paracetamol
[+]

Isoorientin ameliorates acetaminophen-induced hepatotoxicity.Dec 31, 2017

Pubmed Data : Front Pharmacol. 2018 ;9:1334. Epub 2018 Nov 28. PMID: 30546306
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Isoquercitrin could be a potential hepatoprotective agent.Apr 30, 2016

Pubmed Data : Life Sci. 2016 May 1 ;152:180-9. Epub 2016 Apr 3. PMID: 27049115
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Licochalcone A upregulates Nrf2 antioxidant pathway and thereby alleviates acetaminophen-induced hepatotoxicity.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:147. Epub 2018 Mar 23. PMID: 29628888
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Licorice
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Limonin ameliorates acetaminophen-induced hepatotoxicity.Mar 31, 2020

Pubmed Data : Phytomedicine. 2020 Apr ;69:153211. Epub 2020 Mar 20. PMID: 32259676
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Citrus Triterpenoids
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation, SIRT1 Activator
Problem Substances : Acetaminophen, Paracetamol
[+]

Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity.May 01, 2022

Pubmed Data : Drug Chem Toxicol. 2022 May 2:1-9. Epub 2022 May 2. PMID: 35502492
Article Published Date : May 01, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Long-term acetaminophen (paracetamol) treatment causes liver and kidney ultra-structural changes during rat pregnancy.Dec 31, 2003

Pubmed Data : Clin Exp Obstet Gynecol. 2004 ;31(3):221-4. PMID: 15491069
Article Published Date : Dec 31, 2003
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced
Problem Substances : Acetaminophen, Paracetamol
[+]

Lycopene is a natural compound that was able to inhibit the production of ROS and mitigate the damage caused by acetaminophen.Jan 31, 2017

Pubmed Data : Chem Biol Interact. 2017 Feb 1 ;263:7-17. Epub 2016 Dec 15. PMID: 27989599
Article Published Date : Jan 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carotenoids, Lycopene
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Acetaminophen (Tylenol) Toxicity, Antioxidants, CAROTENOIDS, Hepatoprotective, Liver Damage: Drug-Induced, lycopene, Matrix metalloproteinase-2 (MMP-2) inhibitor, oxidative stress
Problem Substances : Acetaminophen, Paracetamol
[+]

Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in mice.Jan 31, 2017

Pubmed Data : Bioorg Med Chem. 2017 Feb 1 ;25(3):1057-1065. Epub 2016 Dec 18. PMID: 28031152
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Acetaminophen (Tylenol) Toxicity, Anti-Inflammatory Agents, Hepatoprotective, Liver Damage: Drug-Induced, lycopene
Problem Substances : Acetaminophen, Paracetamol
[+]

Magnesium hydride protects against acetaminophen-induced acute kidney injury.Nov 30, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ren Fail. 2024 Dec ;46(1):2330629. Epub 2024 Mar 17. PMID: 38494199
Article Published Date : Nov 30, 2024
Study Type : Animal Study
Additional Links
Substances : Magnesium
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Mangiferin ameliorates acetaminophen-induced hepatotoxicity.Jun 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jun 15 ;117:109097. Epub 2019 Jun 15. PMID: 31212128
Article Published Date : Jun 14, 2019
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Acetaminophen, Paracetamol
[+]

Melilotus officinali has strong hepatoprotective activity against paracetamol and carbon tetrachloride induced hepatotoxicity.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pol Pharm. 2017 May ;74(3):903-909. PMID: 29513960
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Yellow Sweet Clover (Melilotus officinalis)
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Methionine in paracetamol tablets, a tool to reduce paracetamol toxicity.Aug 31, 1985

Pubmed Data : Int J Clin Pharmacol Ther Toxicol. 1985 Sep ;23(9):497-500. PMID: 4055163
Article Published Date : Aug 31, 1985
Study Type : Animal Study
Additional Links
Substances : Methionine
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Cytoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Methylsulfonylmethane pre-treatment could alleviate hepatic injury induced by acetaminophen intoxication.Jul 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2013 Aug ;16(8):896-900. PMID: 24106592
Article Published Date : Jul 31, 2013
Study Type : Animal Study
Additional Links
Substances : MSM (Methylsulfonylmethane)
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury.Dec 31, 2023

Pubmed Data : Colloids Surf B Biointerfaces. 2024 Jan ;233:113656. Epub 2023 Nov 15. PMID: 37984191
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Moringa oleifera leaf extracts shielded kidneys from acetaminophen toxicity through enhancement of the endogenous antioxidant system.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PeerJ. 2016 ;4:e2127. Epub 2016 Jul 7. PMID: 27441110
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Myristica fragrans kernels prevent paracetamol-induced hepatotoxicity.Feb 24, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Feb 25 ;20(4). Epub 2019 Feb 25. PMID: 30823534
Article Published Date : Feb 24, 2019
Study Type : Animal Study
Additional Links
Substances : Nutmeg
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

N-acetylcysteine and glycyrrhizin combination: Benefit outcome in a murine model of acetaminophen-induced liver failure.Sep 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Hepatol. 2020 Sep 27 ;12(9):596-618. PMID: 33033567
Article Published Date : Sep 26, 2020
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin, NAC (N-acetyl-L-cysteine)
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Naringin treatment reduced histological alteration induced by APAP in the liver and kidney.Apr 05, 2016

Pubmed Data : Ren Fail. 2016 Apr 6:1-14. Epub 2016 Apr 6. PMID: 27050864
Article Published Date : Apr 05, 2016
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective, MicroRNA modulator, Renoprotective
Problem Substances : Paracetamol
[+]

Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity.Feb 28, 2018

Pubmed Data : Toxicol Sci. 2018 Mar 1 ;162(1):99-112. PMID: 29136249
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid, Polyphenols
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Nephroprotective effect of herbal extract Eurycoma longifolia on paracetamol-induced nephrotoxicity.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:4916519. Epub 2019 May 13. PMID: 31214269
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Tongkat Ali
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced
Pharmacological Actions : Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Nephroprotective property of Trifolium repens leaf extract against paracetamol-induced kidney damage.Nov 30, 2020

Pubmed Data : 3 Biotech. 2020 Dec ;10(12):541. Epub 2020 Nov 19. PMID: 33240744
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : White Clover
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced
Pharmacological Actions : Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Nicotinamide improves NAD + levels to protect against acetaminophen-induced acute liver injury in mice.May 04, 2021

Pubmed Data : Hum Exp Toxicol. 2021 May 5:9603271211014573. Epub 2021 May 5. PMID: 33949241
Article Published Date : May 04, 2021
Study Type : Animal Study
Additional Links
Substances : Nicotinamide
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Nigella sativa extract possesses hepatoprotective action against paracetamol induced acute hepatoxicity. Mar 31, 2014

Pubmed Data : Pak J Biol Sci. 2014 Apr ;17(4):517-22. PMID: 25911839
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Paracetamol
[+]

Nigella sativa has a significant nephroprotective activity on paracetamol-induced nephrotoxicity.Mar 08, 2016

Pubmed Data : Pharm Biol. 2016 Mar 9:1-10. Epub 2016 Mar 9. PMID: 26956915
Article Published Date : Mar 08, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Nigella sativa seed extract has protective effects against acetaminophen induced hepatotoxicity and metabolic disturbances in rats.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2016 Mar ;9(3):221-7. Epub 2016 Jan 13. PMID: 26972391
Article Published Date : Feb 29, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Nimbolide targeting SIRT1 protects against acetaminophen-induced acute liver injury.May 31, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res Perspect. 2025 Jun ;13(3):e70120. PMID: 40375435
Article Published Date : May 31, 2025
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Nobiletin attenuates acetaminophen-induced hepatorenal toxicity.Nov 26, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Nov 27:e22427. Epub 2019 Nov 27. PMID: 31777137
Article Published Date : Nov 26, 2019
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Non-toxic dose of acetaminophen has the potential to increase carbon tetrachloride-induced liver damage and oxidative stress.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2017 ;40(9):1590-1594. PMID: 28867745
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress
Additional Keywords : Synergistic Toxicity
Problem Substances : Acetaminophen, Paracetamol
[+]

Notoginsenoside Fc ameliorates renal tubular injury and mitochondrial damage in acetaminophen-induced acute kidney injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Med (Lausanne). 2022 ;9:1055252. Epub 2023 Jan 6. PMID: 36714147
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Novel pterostilbene-loaded pro-phytomicelles: preclinical pharmacokinetics, distribution, and treatment efficacy against acetaminophen-induced liver injury.Sep 01, 2022

Pubmed Data : Food Funct. 2022 Sep 2. Epub 2022 Sep 2. PMID: 36052647
Article Published Date : Sep 01, 2022
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Opuntia extracts are hepatoprotective and can be used as a nutraceutical to prevent acute liver failure.Oct 03, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 Oct 4 ;8(10). Epub 2016 Oct 4. PMID: 27782042
Article Published Date : Oct 03, 2016
Study Type : Animal Study
Additional Links
Substances : Prickly Pear Cactus
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Oxidative stress in paracetamol-induced pathogenesis: (I). Renal damage.Jan 31, 2005

Pubmed Data : Indian J Biochem Biophys. 2005 Feb ;42(1):59-62. PMID: 23923583
Article Published Date : Jan 31, 2005
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Lipid Peroxidation, Oxidative Stress
Problem Substances : Acetaminophen, Paracetamol
[+]

Ozone showed beneficial effects on acetaminophen hepatotoxicity at a statistically significant level.Nov 12, 2017

Pubmed Data : Pharmacol Rep. 2017 Nov 13 ;70(2):340-345. Epub 2017 Nov 13. PMID: 29477043
Article Published Date : Nov 12, 2017
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity
Therapeutic Actions : Ozone Therapy
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

P. leschenaultii leaves extract protects the liver from paracetamol induced hepatic damage.Mar 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr ;88:1114-1121. Epub 2017 Feb 10. PMID: 28192885
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Passion Flower
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Paracetamol
[+]

P. major extracts attenuate the inflammatory reaction following APAP-induced liver injury. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:347861. Epub 2015 Aug 2. PMID: 26300946
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Plantago major
Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Paeoniflorin attenuates acetaminophen-induced liver injury.Feb 10, 2025

Pubmed Data : Int J Mol Sci. 2025 Feb 11 ;26(4). Epub 2025 Feb 11. PMID: 40003959
Article Published Date : Feb 10, 2025
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Paeoniflorin protects against acetaminophen-induced liver injury.Dec 03, 2022

Pubmed Data : Molecules. 2022 Dec 4 ;27(23). Epub 2022 Dec 4. PMID: 36500627
Article Published Date : Dec 03, 2022
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Paracetamol (acetaminophen) administration during neonatal brain development affects cognitive function and alters its analgesic and anxiolytic response.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Sci. 2014 Mar ;138(1):139-47. Epub 2013 Dec 21. PMID: 24361869
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity
Additional Keywords : Risk Factors
Problem Substances : Acetaminophen, Paracetamol
Adverse Pharmacological Actions : Neurotoxic
[+]

Paracetamol (Acetaminophen) and its effect on the developing mouse brain.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Toxicol. 2022 ;4:867748. Epub 2022 Mar 22. PMID: 35391823
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Brain: Oxidative Stress, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Paracetamol causes endocrine disruption and hepatotoxicity in male fish Rhamdia quelen after subchronic exposure.Jun 30, 2017

Pubmed Data : Environ Toxicol Pharmacol. 2017 Jul ;53:111-120. Epub 2017 May 8. PMID: 28545014
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , DNA damage
Problem Substances : Acetaminophen, Endocrine Disrupting Chemicals (EDCs), Paracetamol
[+]

Paracetamol impairs the profile of amino acids in the rat brain.Dec 31, 2013

Pubmed Data : Environ Toxicol Pharmacol. 2014 Jan ;37(1):95-102. Epub 2013 Nov 13. PMID: 24316461
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity
Problem Substances : Acetaminophen, Paracetamol
[+]

Paracetamol potentiates stress-induced gastric ulceration in rats.Jun 30, 1990

Pubmed Data : J Pharm Pharmacol. 1990 Jul ;42(7):505-7. PMID: 1980294
Article Published Date : Jun 30, 1990
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Gastric Ulcer
Problem Substances : Acetaminophen, Paracetamol
[+]

Paracetamol--the outcome on neurotransmission and spatial learning in rats.Sep 14, 2013

Pubmed Data : Behav Brain Res. 2013 Sep 15 ;253:157-64. Epub 2013 Jul 11. PMID: 23850354
Article Published Date : Sep 14, 2013
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Memory Disorders
Problem Substances : Acetaminophen, Paracetamol
[+]

Paracetamol-induced metabolic and cardiovascular changes are prevented by exercise training.Nov 30, 2020

Pubmed Data : Basic Clin Pharmacol Toxicol. 2020 Dec ;127(6):516-524. Epub 2020 Jul 9. PMID: 32573044
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Oxidative Stress
Therapeutic Actions : Exercise
Pharmacological Actions : Cardioprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Perinatal exposure to paracetamol: Dose and sex-dependent effects in behaviour and brain's oxidative stress markers in progeny.Jun 24, 2021

Pubmed Data : Behav Brain Res. 2021 Jun 25 ;408:113294. Epub 2021 Apr 6. PMID: 33836167
Article Published Date : Jun 24, 2021
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Neurodevelopmental Disorders, Oxidative Stress, Prenatal Chemical Exposures
Additional Keywords : Risk Factors
Problem Substances : Acetaminophen, Paracetamol
Adverse Pharmacological Actions : Neurotoxic
[+]

Phoenix dactylifera protects against oxidative stress and hepatic injury induced by paracetamol intoxication.Jul 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Aug ;104:366-374. Epub 2018 May 25. PMID: 29778019
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Dates
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Piperine as therapeutic agent in paracetamol-induced hepatotoxicity.Aug 25, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceutics. 2022 Aug 26 ;14(9). Epub 2022 Aug 26. PMID: 36145547
Article Published Date : Aug 25, 2022
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation
Problem Substances : Acetaminophen, Paracetamol
[+]

Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury.Aug 31, 2022

Pubmed Data : Phytomedicine. 2022 Sep ;104:154311. Epub 2022 Jul 6. PMID: 35843188
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Substances : Echinacea
Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Hepatoprotective
Additional Keywords : Polysaccharides
Problem Substances : Acetaminophen, Paracetamol
[+]

Polysaccharides from dandelion root have hepatoprotective effects.Aug 24, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Aug 25 ;22(9). Epub 2017 Aug 25. PMID: 28841174
Article Published Date : Aug 24, 2017
Study Type : Animal Study
Additional Links
Substances : Dandelion
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Additional Keywords : Polysaccharides
Problem Substances : Acetaminophen, Paracetamol
[+]

Pomegranate juice might have a preventive effect in paracetamol-induced acute liver damage.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk Pediatri Ars. 2016 Jun ;51(2):72-8. Epub 2016 Jun 1. PMID: 27489463
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Potentiation of gastric toxicity of ibuprofen by paracetamol.Jun 30, 1991

Pubmed Data : J Pharm Pharmacol. 1991 Jul ;43(7):520-1. PMID: 1682470
Article Published Date : Jun 30, 1991
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Gastric Ulcer, Ibuprofen Toxicity
Additional Keywords : Synergistic Toxicity
Problem Substances : Acetaminophen, Ibuprofen, Paracetamol
[+]

Pre-treatment with cinnamon provide potential therapeutic applications in acute liver and kidney injury induced by acetaminophen.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:2285-2292. Epub 2018 Nov 28. PMID: 30551486
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Cinnamon
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective, Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal acetaminophen exposure induces changes of placental morphology and function and its influencing factors.Aug 31, 2025

Pubmed Data : Food Chem Toxicol. 2025 Sep ;203:115598. Epub 2025 Jun 10. PMID: 40505803
Article Published Date : Aug 31, 2025
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring.Apr 30, 2015

Pubmed Data : J Hepatol. 2015 May ;62(5):1085-91. Epub 2014 Dec 18. PMID: 25529619
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Inflammation, Liver Damage: Drug-Induced, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal and postnatal paracetamol exposure results in modulation of cerebellar neurotransmission with changes concerning mainly 5-HIAA and MHPG levels.Nov 30, 2016

Pubmed Data : Pharmacol Rep. 2016 Dec ;68(6):1159-1164. Epub 2016 Sep 7. PMID: 27611980
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures
Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures
Problem Substances : Acetaminophen, Paracetamol
Adverse Pharmacological Actions : Neurotoxic
[+]

Prenatal cigarette smoke exposure sensitizes acetaminophen-induced liver injury by modulating miR-34a-5p in male offspring mice.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Dev Biol. 2024 ;12:1393618. Epub 2024 Jul 30. PMID: 39139452
Article Published Date : Dec 31, 2023
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage, Prenatal Chemical Exposures, Smoking
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal exposure to acetaminophen at different doses, courses and time causes testicular dysplasia in offspring mice and its mechanism.Nov 30, 2023

Pubmed Data : Chemosphere. 2023 Dec ;345:140496. Epub 2023 Oct 19. PMID: 37865203
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures, Testicular Injury: Chemical/Metal Induced
Problem Substances : Acetaminophen, Paracetamol
[+]

Prenatal exposure to acetaminophen may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Reproduction. 2017 Aug ;154(2):145-152. Epub 2017 May 30. PMID: 28559473
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures, Sexual Behavior
Problem Substances : Acetaminophen, Paracetamol
[+]

Preventive effect of methanolic extract of Zataria Multiflora Boiss on liver toxicity of paracetamol.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Life. 2015 ;8(Spec Iss 4):270-274. PMID: 28316743
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Zataria multiflora
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol

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Written by Sayer Ji, Founder
Could this ancient spice be superior to drugs for treating premenstrual syndrome (PMS)?
Eating Sesame Seeds Superior To Tylenol for Knee Arthritis
Written by Sayer Ji, Founder
A remarkable new study published in the International Journal of Rheumatic Diseases confirms that food is not only medicine, but sometimes superior to it.
Top 7 Ways to Keep Baby Safe
Written by Louise Habakus
If what we're doing may contribute to the new normal of childhood chronic illness, then here are 7 bold and brave ways to keep baby safe.
Study Links Tylenol Consumption with Risk Taking
Written by GreenMedInfo Research Group
The psychological side effects of acetaminophen, aka Tylenol, continue to mount, with research showing users are more likely to make risky decisions. When coupled with past research linking this supposedly safe pain reliever to blunted empathy and emotions, the widespread social effects on society could be immense
A Message to Ethical MDs: The Problem with the 2017-8 Flu Vaccine is the 2016-7 Flu Vaccine
Written by James Lyons-Weiler
AMERICANS are highly distracted. They won't recall the efficacy of the flu vaccine from year to year. That's why Sanjay Gupta can go on the news and remind us that his 30% estimate (likely an overestimate) of how well the flu vaccine works is not like past years, the good old days in which the vaccine was 60-70% effective, and not bat an eye
Tylenol Damages The Brains of Children, Research Reveals
Written by William Parker, Ph.D.
Millions use Tylenol on a daily basis without concern, but it has a wide range of toxic side effects you should be aware of, especially if you are pregnant or use it with your children.
The End of Modern Medicine?
Written by Linda Woolven & Ted Snider
“It’s the end of the road for antibiotics unless we act urgently,” - Dr. Tom Friedman

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