Uranium

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17 Diseases Researched for Uranium
NameACCKFocus
Uranium Poisoning2371Locked
Lung Cancer312Locked
Birth Defects110Locked
DNA damage56Locked
Leukemia24Locked
Cancers: Pediatric23Locked
Radiation Induced Illness23Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Cancers: All22Locked
Infertility12Locked
Kidney Damage12Locked
Oxidative Stress12Locked
Testicular Injury: Chemical/Metal Induced12Locked
Bone Cancer11Locked
Immune Disorders: Low Immune Function11Locked
Infertility: Male11Locked
Kaposi's Sarcoma11Locked
12 Adverse Pharmacological Actions Researched for Uranium
NameACCKFocus
Carcinogenic615Locked
Teratogenic211Locked
Genotoxic57Locked
Nephrotoxic24Locked
Hepatotoxic12Locked
Leukemogen12Locked
Neurotoxic12Locked
Renotoxic12Locked
Bioaccumulator11Locked
Cardiotoxic11Locked
Immunotoxic11Locked
Oxidant11Locked

View the Evidence:
37 Abstracts with Uranium Research

[+]

The area of Kosovo appears to be most heavily afflicted by depleted uranium pollution, followed by Bosnia & Herzegovina.Apr 06, 2017

Pubmed Data : J Environ Radioact. 2017 Apr 7 ;172:207-217. Epub 2017 Apr 7. PMID: 28395154
Article Published Date : Apr 06, 2017
Study Type : Meta Analysis
Additional Links
Problem Substances : Uranium: Depleted
[+]

Fragment retainment and related scarring was significantly increased in veterans exposed to high levels of DU.Apr 30, 2015

Pubmed Data : Dermatitis. 2015 May-Jun;26(3):142-7. PMID: 25984691
Article Published Date : Apr 30, 2015
Study Type : Human Study
Additional Links
Diseases : Uranium Poisoning
Problem Substances : Uranium: Depleted
[+]

Human epidemiological evidence is consistent with increased risk of birth defects in offspring of persons exposed to depleted uranium.Jan 01, 2005

Pubmed Data : Environ Health. 2005;4:17. Epub 2005 Aug 26. PMID: 16124873
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Diseases : Birth Defects
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Teratogenic
[+]

Lung cancer incidence is higher in populations living near uranium milling and mining operations. Nov 01, 2010

Pubmed Data : Radiat Res. 2010 Nov;174(5):624-36. Epub 2010 Sep 13. PMID: 20954862
Article Published Date : Nov 01, 2010
Study Type : Human Study
Additional Links
Diseases : Lung Cancer
Problem Substances : Uranium
Adverse Pharmacological Actions : Carcinogenic
[+]

Modified citrus pectin and alginate dietary supplement increased fecal excretion of uranium.Jun 30, 2019

Pubmed Data : Altern Ther Health Med. 2019 Jul ;25(4):20-24. PMID: 31202207
Article Published Date : Jun 30, 2019
Study Type : Human Study
Additional Links
Substances : Modified Citrus Pectin , Sodium Alginate
Diseases : Uranium Poisoning
Pharmacological Actions : Detoxifier
Problem Substances : Uranium
[+]

More than 5 metric tons of depleted uranium was deposited as microscopic DU oxide particles on the plant site and surrounding residential community.Sep 30, 2016

Pubmed Data : Environ Res. 2016 Oct ;150:629-38. Epub 2016 May 12. PMID: 27179584
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Diseases : Uranium Poisoning
Problem Substances : Uranium: Depleted
[+]

When exposure to aerosol has been unambiguous and in sufficient quantity, urinary excretion of DU can be detected more than 20 years.Jan 31, 2008

Pubmed Data : Sci Total Environ. 2008 Feb 1 ;390(1):58-68. Epub 2007 Oct 31. PMID: 17976690
Article Published Date : Jan 31, 2008
Study Type : Human Study
Additional Links
Diseases : Uranium Poisoning
Problem Substances : Uranium: Depleted
[+]

This study found that the Uranium residence half-life in the skeleton was significantly greater than the half-time proposed by ICRP.Aug 31, 2015

Pubmed Data : Health Phys. 2015 Sep ;109(3):187-97. PMID: 26222213
Article Published Date : Aug 31, 2015
Study Type : Human: Case Report
Additional Links
Diseases : Uranium Poisoning
Additional Keywords : Risk Factors
Problem Substances : Radionuclides, Uranium: Depleted
[+]

Acetaminophen (Tylenol) includes the toxicity associated with chronic exposure to depleted uranium. Jan 05, 2007

Pubmed Data : Toxicology. 2007 Jan 5;229(1-2):62-72. Epub 2006 Oct 17. PMID: 17126469
Article Published Date : Jan 05, 2007
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity , Uranium Poisoning
Additional Keywords : Toxic Substance Synergy
Problem Substances : Tylenol, Uranium
Adverse Pharmacological Actions : Hepatotoxic, Nephrotoxic
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Cell proliferation and cell death are disturbed during prenatal and postnatal brain development after uranium exposure.Dec 31, 2015

Pubmed Data : Neurotoxicology. 2016 Jan ;52:34-45. Epub 2015 Oct 23. PMID: 26506049
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Uranium Poisoning
Problem Substances : Uranium: Depleted
[+]

Depleted uranium induces leukemia in heatopoietic cells in mice. Nov 01, 2005

Pubmed Data : Mol Cell Biochem. 2005 Nov;279(1-2):97-104. PMID: 16283518
Article Published Date : Nov 01, 2005
Study Type : Animal Study
Additional Links
Diseases : Leukemia
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Leukemogen
[+]

Depleted uranium may cause genetic damage that is passed transgenerationally down to offspring. Sep 01, 2010

Pubmed Data : Health Phys. 2010 Sep;99(3):371-9. PMID: 20699700
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Cancers: Pediatric, DNA damage, Leukemia, Radiation Induced Illness
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Genotoxic
[+]

Dietary uranium inhibits reproductive processes. Jan 01, 2011

Pubmed Data : Environ Toxicol Chem. 2011 Jan;30(1):220-5. PMID: 20963820
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Infertility
Problem Substances : Uranium
[+]

Differential protein expression in metallothionein protection from depleted uranium-induced nephrotoxicityDec 13, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Dec 14 ;6:38942. Epub 2016 Dec 14. PMID: 27966587
Article Published Date : Dec 13, 2016
Study Type : Animal Study
Additional Links
Diseases : Uranium Poisoning
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Renotoxic
[+]

Endocrine effects of lifelong exposure to low-dose depleted uranium on testicular functions in adult rat.Aug 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicology. 2016 Aug 10 ;368-369:58-68. Epub 2016 Aug 17. PMID: 27544493
Article Published Date : Aug 09, 2016
Study Type : Animal Study
Additional Links
Problem Substances : Uranium: Depleted
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Exposure to depleted uranium during gestation and lactation affects brain development in embryos, fetuses and neonates.Nov 30, 2016

Pubmed Data : Neurotoxicology. 2016 Dec ;57:153-162. Epub 2016 Sep 14. PMID: 27639536
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Diseases : Uranium Poisoning
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Neurotoxic
[+]

Exposure to environmentally relevant concentrations of uranium could induce transgenerational epigenetic effects.Mar 31, 2016

Pubmed Data : J Environ Radioact. 2016 Apr ;154:25-33. Epub 2016 Jan 29. PMID: 26829549
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Uranium Poisoning
Additional Keywords : Transgenerational Epigenetic Modification
Problem Substances : Uranium: Depleted
[+]

Host-microbiota interactions are potentially disturbed in response to uranium induced stress.Mar 31, 2015

Pubmed Data : J Environ Radioact. 2015 Apr ;142:45-53. Epub 2015 Jan 27. PMID: 25633624
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Uranium Poisoning
Additional Keywords : Microbiota
Problem Substances : Uranium: Depleted
[+]

Metallothioneins protect against depleted uranium toxicity in a Caenorhabditis elegans experimental model. Oct 01, 2009

Pubmed Data : Toxicol Sci. 2009 Oct;111(2):345-54. Epub 2009 Jul 17. PMID: 19617453
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Uranium Poisoning
Problem Substances : Uranium
[+]

These data reveal the extreme sensitivity of zebrafish embryos to depleted uranium transmitted through the oocyte by exposed females.Feb 28, 2017

Pubmed Data : Aquat Toxicol. 2017 Mar ;184:14-25. Epub 2016 Dec 8. PMID: 28068562
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Diseases : Uranium Poisoning
Additional Keywords : DNA Methylation, Transgenerational Epigenetic Modification
Problem Substances : Uranium: Depleted
[+]

These findings support the potential of licorice and its active ingredient, glycyrrhizic acid, as promising candidates for uranium decorporation agents.Jul 04, 2024

Pubmed Data : Inorg Chem. 2024 Jul 5. Epub 2024 Jul 5. PMID: 38967129
Article Published Date : Jul 04, 2024
Study Type : Animal Study
Additional Links
Substances : Licorice
Diseases : Uranium Poisoning
Pharmacological Actions : Detoxifier
Additional Keywords : Natural Substances Versus Drugs, Superiority of Natural Substances versus Drugs
Problem Substances : Uranium
[+]

Thymoquinone and NAC attenuate uranyl acetate adverse effects on the testicular microenvironement.Dec 13, 2018

Pubmed Data : Gen Physiol Biophys. 2018 Dec 14. Epub 2018 Dec 14. PMID: 30547892
Article Published Date : Dec 13, 2018
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Thymoquinone
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic, Cytoprotective
Problem Substances : Uranium: Depleted
[+]

Uranium nitrate is renotoxic and dramatically alters the expression of more than 200 genes in the rat kidney. Nov 01, 2004

Pubmed Data : Environ Health Perspect. 2004 Nov;112(16):1628-35. PMID: 15598614
Article Published Date : Nov 01, 2004
Study Type : Animal Study
Additional Links
Diseases : Kidney Damage, Oxidative Stress, Uranium Poisoning
Problem Substances : Uranium
Adverse Pharmacological Actions : Genotoxic, Nephrotoxic
[+]

Depleted uranium (Uranium-238) has been shown to induce adverse cellular changes associated with oxidative stress (without alpha particle decay) at a rate one million fold higher than caused by radiolytic generation. Jul 25, 2002

Pubmed Data : J Inorg Biochem. 2002 Jul 25;91(1):246-52. PMID: 12121782
Article Published Date : Jul 25, 2002
Study Type : Review
Additional Links
Diseases : DNA damage
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Genotoxic, Oxidant
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Depleted uranium does not activate the p53 tumor suppressor protein as do other toxic metal complexes, indicating a mechanism for its carcinogenicity. Feb 01, 2011

Pubmed Data : J Inorg Biochem. 2011 Feb;105(2):142-8. Epub 2010 Oct 29. PMID: 21194611
Article Published Date : Feb 01, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Cancers: All, DNA damage
Problem Substances : Uranium: Depleted
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Depleted uranium has genotoxic, carcinogenic and mutagenic properties.Jun 01, 2001

Pubmed Data : Toxicol Ind Health. 2001 Jun;17(5-10):180-91. PMID: 12539863
Article Published Date : Jun 01, 2001
Study Type : Review
Additional Links
Diseases : Infertility: Male
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Cardiotoxic, Genotoxic, Teratogenic
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Depleted uranium induces neoplastic transformation in human lung epithelial cells.Feb 15, 2010

Pubmed Data : Chem Res Toxicol. 2010 Feb 15;23(2):373-8. PMID: 20000475
Article Published Date : Feb 15, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Lung Cancer, Uranium Poisoning
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Carcinogenic
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Depleted uranium is capable of transforming human bone cells into expressing a tumorous phenotype.Aug 01, 1998

Pubmed Data : Environ Health Perspect. 1998 Aug;106(8):465-71. PMID: 9681973
Article Published Date : Aug 01, 1998
Study Type : In Vitro Study
Additional Links
Diseases : Bone Cancer
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Carcinogenic
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Depleted uranium may be responsible for the recent upsurge of malignancies in populations exposed to war dust.May 01, 2012

Pubmed Data : Saudi Med J. 2012 May ;33(5):483-8. PMID: 22588807
Article Published Date : May 01, 2012
Study Type : Review
Additional Links
Diseases : Cancers: Pediatric, Kaposi's Sarcoma, Uranium Poisoning
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Carcinogenic
[+]

Depleted uranium-uranyl chloride induces cell death in mouse macrophages.Sep 30, 2002

Pubmed Data : Toxicology. 2002 Sep 30;179(1-2):105-14. PMID: 12204547
Article Published Date : Sep 30, 2002
Study Type : In Vitro Study
Additional Links
Diseases : Immune Disorders: Low Immune Function
Problem Substances : Uranium
Adverse Pharmacological Actions : Immunotoxic
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Despite the relatively low specific activity of depleted uranium as a radiogenic substance, it is capable of inducing cancer at exceedingly small concentrations. Jan 01, 2002

Pubmed Data : Radiat Prot Dosimetry. 2002;99(1-4):275-8. PMID: 12194305
Article Published Date : Jan 01, 2002
Study Type : In Vitro Study
Additional Links
Diseases : Cancers: All, DNA damage, Radiation Induced Illness, Uranium Poisoning
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Carcinogenic
[+]

Glyphosphate increases the bioaccumulation of depleted uranium in plants 17 fold. Aug 01, 2010

Pubmed Data : Int J Phytoremediation. 2010 Aug;12(6):550-61. PMID: 21166280
Article Published Date : Aug 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Uranium Poisoning
Additional Keywords : Problem Substance Synergy
Problem Substances : Glyphosate, Uranium
Adverse Pharmacological Actions : Bioaccumulator
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Particulate depleted uranium is cytotoxic and clastogenic to human lung epithelial cells.Mar 29, 2010

Pubmed Data : Mutat Res. 2010 Mar 29;697(1-2):33-7. Epub 2010 Feb 19. PMID: 20172046
Article Published Date : Mar 29, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Lung Cancer, Uranium Poisoning
Problem Substances : Uranium: Depleted
Adverse Pharmacological Actions : Carcinogenic
[+]

There is natural radioactivity and heavy metals in crude oils that may pose a health risk. Feb 01, 2009

Pubmed Data : Environ Geochem Health. 2009 Feb;31(1):61-9. Epub 2008 Mar 5. PMID: 18320332
Article Published Date : Feb 01, 2009
Study Type : Review
Additional Links
Diseases : Uranium Poisoning
Additional Keywords : Outdated Radiation Risk Model
Problem Substances : Crude Oil/Petroleum, Uranium
[+]

Uranium concentrations in South African herbal remedies range between 15-40 ppm.Dec 01, 2005

Pubmed Data : Health Phys. 2005 Dec;89(6):679-83. PMID: 16282800
Article Published Date : Dec 01, 2005
Study Type : Review
Additional Links
Problem Substances : Uranium
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Uranyl ions are highly genotoxic and their genotoxicity are enhanced by heat and gamma-irradiation. May 01, 2005

Pubmed Data : Biofizika. 2005 May-Jun;50(3):456-63. PMID: 15977835
Article Published Date : May 01, 2005
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage, Uranium Poisoning
Problem Substances : Uranium, Uranyl Acetate
Adverse Pharmacological Actions : Genotoxic
[+]

Water-soluble imprinted cross-linked chitosan may detoxify the body of depleted uranium.May 01, 2011

Pubmed Data : Yao Xue Xue Bao. 2011 May ;46(5):513-20. PMID: 21800537
Article Published Date : May 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Chitosan
Diseases : Uranium Poisoning
Pharmacological Actions : Detoxifier: Radionuclide Removal
Problem Substances : Uranium: Depleted

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